PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Kalanchoe laxiflora
HD-ZIP Family
Species TF ID Description
Kaladp0101s0273.1.pHD-ZIP family protein
Kaladp0071s0123.1.pHD-ZIP family protein
Kaladp1246s0007.1.pHD-ZIP family protein
Kaladp0045s0032.1.pHD-ZIP family protein
Kaladp0047s0272.1.pHD-ZIP family protein
Kaladp0674s0135.1.pHD-ZIP family protein
Kaladp0844s0013.1.pHD-ZIP family protein
Kaladp0024s0501.1.pHD-ZIP family protein
Kaladp0418s0006.1.pHD-ZIP family protein
Kaladp0048s0910.1.pHD-ZIP family protein
Kaladp0323s0002.1.pHD-ZIP family protein
Kaladp0079s0030.2.pHD-ZIP family protein
Kaladp0079s0030.1.pHD-ZIP family protein
Kaladp0068s0292.1.pHD-ZIP family protein
Kaladp0076s0024.1.pHD-ZIP family protein
Kaladp0095s0223.2.pHD-ZIP family protein
Kaladp0095s0223.1.pHD-ZIP family protein
Kaladp0079s0160.1.pHD-ZIP family protein
Kaladp0023s0075.1.pHD-ZIP family protein
Kaladp0038s0031.1.pHD-ZIP family protein
Kaladp0070s0052.1.pHD-ZIP family protein
Kaladp0099s0120.1.pHD-ZIP family protein
Kaladp0064s0028.1.pHD-ZIP family protein
Kaladp0059s0291.1.pHD-ZIP family protein
Kaladp0031s0028.1.pHD-ZIP family protein
Kaladp0008s0096.1.pHD-ZIP family protein
Kaladp0040s0209.1.pHD-ZIP family protein
Kaladp0808s0045.1.pHD-ZIP family protein
Kaladp1129s0026.1.pHD-ZIP family protein
Kaladp0040s0540.1.pHD-ZIP family protein
Kaladp0055s0296.1.pHD-ZIP family protein
Kaladp0607s0011.1.pHD-ZIP family protein
Kaladp0098s0053.1.pHD-ZIP family protein
Kaladp0177s0003.1.pHD-ZIP family protein
Kaladp0034s0004.1.pHD-ZIP family protein
Kaladp0042s0372.1.pHD-ZIP family protein
Kaladp0060s0101.1.pHD-ZIP family protein
Kaladp0060s0100.1.pHD-ZIP family protein
Kaladp0014s0013.1.pHD-ZIP family protein
Kaladp0067s0047.1.pHD-ZIP family protein
Kaladp0024s0900.1.pHD-ZIP family protein
Kaladp0042s0326.1.pHD-ZIP family protein
Kaladp0040s0359.1.pHD-ZIP family protein
Kaladp0009s0077.1.pHD-ZIP family protein
Kaladp0022s0030.1.pHD-ZIP family protein
Kaladp0045s0475.1.pHD-ZIP family protein
Kaladp0045s0475.2.pHD-ZIP family protein
Kaladp0031s0057.1.pHD-ZIP family protein
Kaladp0031s0057.2.pHD-ZIP family protein
Kaladp0031s0057.3.pHD-ZIP family protein
Kaladp0015s0142.1.pHD-ZIP family protein
Kaladp0043s0282.2.pHD-ZIP family protein
Kaladp0043s0282.1.pHD-ZIP family protein
Kaladp0093s0030.1.pHD-ZIP family protein
Kaladp0055s0365.1.pHD-ZIP family protein
Kaladp0095s0509.1.pHD-ZIP family protein
Kaladp0067s0313.2.pHD-ZIP family protein
Kaladp0067s0313.1.pHD-ZIP family protein
Kaladp0043s0276.1.pHD-ZIP family protein
Kaladp0092s0159.1.pHD-ZIP family protein
Kaladp0278s0025.2.pHD-ZIP family protein
Kaladp0278s0025.1.pHD-ZIP family protein
Kaladp0008s0827.1.pHD-ZIP family protein
Kaladp0008s0827.2.pHD-ZIP family protein
Kaladp0008s0827.3.pHD-ZIP family protein
Kaladp0039s0699.1.pHD-ZIP family protein
Kaladp0039s0699.2.pHD-ZIP family protein
Kaladp0081s0257.1.pHD-ZIP family protein
Kaladp0081s0257.2.pHD-ZIP family protein
Kaladp0033s0006.1.pHD-ZIP family protein
Kaladp0085s0044.1.pHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401