PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Juglans regia
bHLH Family
Species TF ID Description
WALNUT_00000132-RAbHLH family protein
WALNUT_00000666-RAbHLH family protein
WALNUT_00000704-RAbHLH family protein
WALNUT_00000787-RAbHLH family protein
WALNUT_00000882-RAbHLH family protein
WALNUT_00001012-RAbHLH family protein
WALNUT_00001188-RAbHLH family protein
WALNUT_00001299-RAbHLH family protein
WALNUT_00001364-RAbHLH family protein
WALNUT_00001618-RAbHLH family protein
WALNUT_00001984-RAbHLH family protein
WALNUT_00002151-RAbHLH family protein
WALNUT_00003264-RAbHLH family protein
WALNUT_00003907-RAbHLH family protein
WALNUT_00004412-RAbHLH family protein
WALNUT_00005519-RAbHLH family protein
WALNUT_00005552-RAbHLH family protein
WALNUT_00005570-RAbHLH family protein
WALNUT_00006409-RAbHLH family protein
WALNUT_00006897-RAbHLH family protein
WALNUT_00007485-RAbHLH family protein
WALNUT_00007648-RAbHLH family protein
WALNUT_00007907-RAbHLH family protein
WALNUT_00008391-RAbHLH family protein
WALNUT_00008397-RAbHLH family protein
WALNUT_00008492-RAbHLH family protein
WALNUT_00008945-RAbHLH family protein
WALNUT_00008952-RAbHLH family protein
WALNUT_00009119-RAbHLH family protein
WALNUT_00009338-RAbHLH family protein
WALNUT_00009341-RAbHLH family protein
WALNUT_00010124-RAbHLH family protein
WALNUT_00010824-RAbHLH family protein
WALNUT_00010978-RAbHLH family protein
WALNUT_00011010-RAbHLH family protein
WALNUT_00011193-RAbHLH family protein
WALNUT_00011473-RAbHLH family protein
WALNUT_00011517-RAbHLH family protein
WALNUT_00011799-RAbHLH family protein
WALNUT_00011993-RAbHLH family protein
WALNUT_00012013-RAbHLH family protein
WALNUT_00012203-RAbHLH family protein
WALNUT_00012211-RAbHLH family protein
WALNUT_00012684-RAbHLH family protein
WALNUT_00013001-RAbHLH family protein
WALNUT_00013201-RAbHLH family protein
WALNUT_00013282-RAbHLH family protein
WALNUT_00013347-RAbHLH family protein
WALNUT_00013686-RAbHLH family protein
WALNUT_00014446-RAbHLH family protein
WALNUT_00014878-RAbHLH family protein
WALNUT_00015007-RAbHLH family protein
WALNUT_00015734-RAbHLH family protein
WALNUT_00015921-RAbHLH family protein
WALNUT_00015971-RAbHLH family protein
WALNUT_00016051-RAbHLH family protein
WALNUT_00016233-RAbHLH family protein
WALNUT_00016528-RAbHLH family protein
WALNUT_00016725-RAbHLH family protein
WALNUT_00017075-RAbHLH family protein
WALNUT_00017149-RAbHLH family protein
WALNUT_00017336-RAbHLH family protein
WALNUT_00017612-RAbHLH family protein
WALNUT_00017815-RAbHLH family protein
WALNUT_00017899-RAbHLH family protein
WALNUT_00018151-RAbHLH family protein
WALNUT_00018476-RAbHLH family protein
WALNUT_00018589-RAbHLH family protein
WALNUT_00018755-RAbHLH family protein
WALNUT_00018763-RAbHLH family protein
WALNUT_00018903-RAbHLH family protein
WALNUT_00019905-RAbHLH family protein
WALNUT_00019996-RAbHLH family protein
WALNUT_00020022-RAbHLH family protein
WALNUT_00020108-RAbHLH family protein
WALNUT_00020185-RAbHLH family protein
WALNUT_00020404-RAbHLH family protein
WALNUT_00020407-RAbHLH family protein
WALNUT_00020634-RAbHLH family protein
WALNUT_00020848-RAbHLH family protein
WALNUT_00021702-RAbHLH family protein
WALNUT_00021891-RAbHLH family protein
WALNUT_00021945-RAbHLH family protein
WALNUT_00021948-RAbHLH family protein
WALNUT_00021952-RAbHLH family protein
WALNUT_00022884-RAbHLH family protein
WALNUT_00022948-RAbHLH family protein
WALNUT_00023299-RAbHLH family protein
WALNUT_00023573-RAbHLH family protein
WALNUT_00023638-RAbHLH family protein
WALNUT_00023721-RAbHLH family protein
WALNUT_00024103-RAbHLH family protein
WALNUT_00024129-RAbHLH family protein
WALNUT_00024259-RAbHLH family protein
WALNUT_00024529-RAbHLH family protein
WALNUT_00024530-RAbHLH family protein
WALNUT_00024618-RAbHLH family protein
WALNUT_00024701-RAbHLH family protein
WALNUT_00024726-RAbHLH family protein
WALNUT_00024912-RAbHLH family protein
WALNUT_00024941-RAbHLH family protein
WALNUT_00025246-RAbHLH family protein
WALNUT_00025987-RAbHLH family protein
WALNUT_00026186-RAbHLH family protein
WALNUT_00026549-RAbHLH family protein
WALNUT_00026938-RAbHLH family protein
WALNUT_00027217-RAbHLH family protein
WALNUT_00027279-RAbHLH family protein
WALNUT_00027280-RAbHLH family protein
WALNUT_00027404-RAbHLH family protein
WALNUT_00027715-RAbHLH family protein
WALNUT_00027734-RAbHLH family protein
WALNUT_00027735-RAbHLH family protein
WALNUT_00028089-RAbHLH family protein
WALNUT_00028164-RAbHLH family protein
WALNUT_00028717-RAbHLH family protein
WALNUT_00029052-RAbHLH family protein
WALNUT_00029239-RAbHLH family protein
WALNUT_00029977-RAbHLH family protein
WALNUT_00030273-RAbHLH family protein
WALNUT_00030451-RAbHLH family protein
WALNUT_00030817-RAbHLH family protein
WALNUT_00031734-RAbHLH family protein
WALNUT_00031751-RAbHLH family protein
WALNUT_00031972-RAbHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250