PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Jatropha curcas
bHLH Family
Species TF ID Description
Jcr4S00027.270bHLH family protein
Jcr4S00030.280bHLH family protein
Jcr4S00039.170bHLH family protein
Jcr4S00043.30bHLH family protein
Jcr4S00053.100bHLH family protein
Jcr4S00056.100bHLH family protein
Jcr4S00074.50bHLH family protein
Jcr4S00094.130bHLH family protein
Jcr4S00094.180bHLH family protein
Jcr4S00097.40bHLH family protein
Jcr4S00113.50bHLH family protein
Jcr4S00190.100bHLH family protein
Jcr4S00190.20bHLH family protein
Jcr4S00223.20bHLH family protein
Jcr4S00312.130bHLH family protein
Jcr4S00356.150bHLH family protein
Jcr4S00361.90bHLH family protein
Jcr4S00374.80bHLH family protein
Jcr4S00398.80bHLH family protein
Jcr4S00458.60bHLH family protein
Jcr4S00462.30bHLH family protein
Jcr4S00476.40bHLH family protein
Jcr4S00501.30bHLH family protein
Jcr4S00545.60bHLH family protein
Jcr4S00578.30bHLH family protein
Jcr4S00617.160bHLH family protein
Jcr4S00699.20bHLH family protein
Jcr4S00784.10bHLH family protein
Jcr4S00872.50bHLH family protein
Jcr4S00872.60bHLH family protein
Jcr4S00892.10bHLH family protein
Jcr4S00894.30bHLH family protein
Jcr4S00909.50bHLH family protein
Jcr4S00912.10bHLH family protein
Jcr4S00945.40bHLH family protein
Jcr4S00957.50bHLH family protein
Jcr4S00969.70bHLH family protein
Jcr4S01003.10bHLH family protein
Jcr4S01019.40bHLH family protein
Jcr4S01064.10bHLH family protein
Jcr4S01114.30bHLH family protein
Jcr4S01116.40bHLH family protein
Jcr4S01122.10bHLH family protein
Jcr4S01129.40bHLH family protein
Jcr4S01174.60bHLH family protein
Jcr4S01302.70bHLH family protein
Jcr4S01323.80bHLH family protein
Jcr4S01386.20bHLH family protein
Jcr4S01414.70bHLH family protein
Jcr4S01508.60bHLH family protein
Jcr4S01606.30bHLH family protein
Jcr4S01679.50bHLH family protein
Jcr4S01732.10bHLH family protein
Jcr4S01784.40bHLH family protein
Jcr4S01883.30bHLH family protein
Jcr4S01938.10bHLH family protein
Jcr4S01963.30bHLH family protein
Jcr4S02020.40bHLH family protein
Jcr4S02077.20bHLH family protein
Jcr4S02087.30bHLH family protein
Jcr4S02109.10bHLH family protein
Jcr4S02285.60bHLH family protein
Jcr4S02287.10bHLH family protein
Jcr4S02347.10bHLH family protein
Jcr4S02369.30bHLH family protein
Jcr4S02384.70bHLH family protein
Jcr4S02591.30bHLH family protein
Jcr4S02724.10bHLH family protein
Jcr4S02785.30bHLH family protein
Jcr4S02861.50bHLH family protein
Jcr4S02879.60bHLH family protein
Jcr4S02905.50bHLH family protein
Jcr4S02942.60bHLH family protein
Jcr4S02999.50bHLH family protein
Jcr4S03546.70bHLH family protein
Jcr4S03571.20bHLH family protein
Jcr4S03984.30bHLH family protein
Jcr4S04149.70bHLH family protein
Jcr4S04149.80bHLH family protein
Jcr4S04356.10bHLH family protein
Jcr4S04597.10bHLH family protein
Jcr4S04660.10bHLH family protein
Jcr4S04660.30bHLH family protein
Jcr4S04839.30bHLH family protein
Jcr4S04900.20bHLH family protein
Jcr4S04936.40bHLH family protein
Jcr4S05150.10bHLH family protein
Jcr4S05342.40bHLH family protein
Jcr4S05589.10bHLH family protein
Jcr4S05660.20bHLH family protein
Jcr4S05684.30bHLH family protein
Jcr4S05700.10bHLH family protein
Jcr4S05921.20bHLH family protein
Jcr4S06397.10bHLH family protein
Jcr4S06462.20bHLH family protein
Jcr4S06478.40bHLH family protein
Jcr4S06590.10bHLH family protein
Jcr4S06653.20bHLH family protein
Jcr4S07213.10bHLH family protein
Jcr4S07213.30bHLH family protein
Jcr4S07384.20bHLH family protein
Jcr4S07615.20bHLH family protein
Jcr4S09365.20bHLH family protein
Jcr4S10885.10bHLH family protein
Jcr4S11708.10bHLH family protein
Jcr4S11776.10bHLH family protein
Jcr4S13810.10bHLH family protein
Jcr4S17589.10bHLH family protein
Jcr4S25056.10bHLH family protein
Jcr4S25457.10bHLH family protein
Jcr4S25476.30bHLH family protein
Jcr4S26187.10bHLH family protein
Jcr4U30797.10bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250