PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Jatropha curcas
HD-ZIP Family
Species TF ID Description
Jcr4S03917.20HD-ZIP family protein
Jcr4S00115.240HD-ZIP family protein
Jcr4S00244.90HD-ZIP family protein
Jcr4S01788.10HD-ZIP family protein
Jcr4S02196.90HD-ZIP family protein
Jcr4S10510.10HD-ZIP family protein
Jcr4S06647.20HD-ZIP family protein
Jcr4S00609.90HD-ZIP family protein
Jcr4S00845.50HD-ZIP family protein
Jcr4S04808.40HD-ZIP family protein
Jcr4S01359.50HD-ZIP family protein
Jcr4S02546.10HD-ZIP family protein
Jcr4S03691.50HD-ZIP family protein
Jcr4S06344.30HD-ZIP family protein
Jcr4S03153.10HD-ZIP family protein
Jcr4S20723.10HD-ZIP family protein
Jcr4S10938.10HD-ZIP family protein
Jcr4S19763.20HD-ZIP family protein
Jcr4S00968.40HD-ZIP family protein
Jcr4S00108.20HD-ZIP family protein
Jcr4S11989.10HD-ZIP family protein
Jcr4S00483.60HD-ZIP family protein
Jcr4S27009.10HD-ZIP family protein
Jcr4S02751.60HD-ZIP family protein
Jcr4S16562.10HD-ZIP family protein
Jcr4S01139.30HD-ZIP family protein
Jcr4S00247.50HD-ZIP family protein
Jcr4S05562.10HD-ZIP family protein
Jcr4S06164.20HD-ZIP family protein
Jcr4S00028.70HD-ZIP family protein
Jcr4S01785.10HD-ZIP family protein
Jcr4S05250.20HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401