PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Ipomoea trifida
HD-ZIP Family
Species TF ID Description
Itr_sc000974.1_g00003.1HD-ZIP family protein
Itr_sc000141.1_g00019.1HD-ZIP family protein
Itr_sc001935.1_g00005.1HD-ZIP family protein
Itr_sc000314.1_g00002.1HD-ZIP family protein
Itr_sc000063.1_g00009.1HD-ZIP family protein
Itr_sc000162.1_g00021.1HD-ZIP family protein
Itr_sc000807.1_g00004.1HD-ZIP family protein
Itr_sc000178.1_g00032.1HD-ZIP family protein
Itr_sc002159.1_g00002.1HD-ZIP family protein
Itr_sc000180.1_g00019.1HD-ZIP family protein
Itr_sc000232.1_g00016.1HD-ZIP family protein
Itr_sc000144.1_g00012.1HD-ZIP family protein
Itr_sc000897.1_g00035.1HD-ZIP family protein
Itr_sc000022.1_g00011.1HD-ZIP family protein
Itr_sc000016.1_g00032.1HD-ZIP family protein
Itr_sc000583.1_g00017.1HD-ZIP family protein
Itr_sc000960.1_g00003.1HD-ZIP family protein
Itr_sc002378.1_g00002.1HD-ZIP family protein
Itr_sc003864.1_g00001.1HD-ZIP family protein
Itr_sc000287.1_g00009.1HD-ZIP family protein
Itr_sc001863.1_g00015.1HD-ZIP family protein
Itr_sc000006.1_g00058.1HD-ZIP family protein
Itr_sc000236.1_g00010.1HD-ZIP family protein
Itr_sc000062.1_g00018.1HD-ZIP family protein
Itr_sc003675.1_g00001.1HD-ZIP family protein
Itr_sc001280.1_g00009.1HD-ZIP family protein
Itr_sc000477.1_g00008.1HD-ZIP family protein
Itr_sc000159.1_g00033.1HD-ZIP family protein
Itr_sc003050.1_g00006.1HD-ZIP family protein
Itr_sc000200.1_g00008.1HD-ZIP family protein
Itr_sc001518.1_g00007.1HD-ZIP family protein
Itr_sc000656.1_g00001.1HD-ZIP family protein
Itr_sc001115.1_g00003.1HD-ZIP family protein
Itr_sc000904.1_g00004.1HD-ZIP family protein
Itr_sc001296.1_g00009.1HD-ZIP family protein
Itr_sc000157.1_g00005.1HD-ZIP family protein
Itr_sc001985.1_g00005.1HD-ZIP family protein
Itr_sc000580.1_g00026.1HD-ZIP family protein
Itr_sc000494.1_g00001.1HD-ZIP family protein
Itr_sc000028.1_g00009.1HD-ZIP family protein
Itr_sc000159.1_g00042.1HD-ZIP family protein
Itr_sc003412.1_g00001.1HD-ZIP family protein
Itr_sc001316.1_g00005.1HD-ZIP family protein
Itr_sc002208.1_g00004.1HD-ZIP family protein
Itr_sc004345.1_g00001.1HD-ZIP family protein
Itr_sc000069.1_g00074.1HD-ZIP family protein
Itr_sc000269.1_g00012.1HD-ZIP family protein
Itr_sc000451.1_g00024.1HD-ZIP family protein
Itr_sc000829.1_g00003.1HD-ZIP family protein
Itr_sc001830.1_g00004.1HD-ZIP family protein
Itr_sc000623.1_g00003.1HD-ZIP family protein
Itr_sc000793.1_g00023.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401