PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Hordeum vulgare
bHLH Family
Species TF ID Description
MLOC_10595.1bHLH family protein
MLOC_10595.2bHLH family protein
MLOC_10815.1bHLH family protein
MLOC_10815.10bHLH family protein
MLOC_10815.2bHLH family protein
MLOC_10815.3bHLH family protein
MLOC_10815.4bHLH family protein
MLOC_12058.1bHLH family protein
MLOC_12058.2bHLH family protein
MLOC_12058.3bHLH family protein
MLOC_12832.1bHLH family protein
MLOC_12832.3bHLH family protein
MLOC_13159.1bHLH family protein
MLOC_13438.2bHLH family protein
MLOC_13438.3bHLH family protein
MLOC_13653.1bHLH family protein
MLOC_15000.1bHLH family protein
MLOC_16429.1bHLH family protein
MLOC_16609.1bHLH family protein
MLOC_16609.2bHLH family protein
MLOC_16609.3bHLH family protein
MLOC_16609.5bHLH family protein
MLOC_17549.1bHLH family protein
MLOC_20318.1bHLH family protein
MLOC_20318.2bHLH family protein
MLOC_20318.3bHLH family protein
MLOC_21524.1bHLH family protein
MLOC_21759.1bHLH family protein
MLOC_21759.2bHLH family protein
MLOC_2366.1bHLH family protein
MLOC_30102.1bHLH family protein
MLOC_30102.2bHLH family protein
MLOC_30102.3bHLH family protein
MLOC_30102.4bHLH family protein
MLOC_33189.1bHLH family protein
MLOC_33189.2bHLH family protein
MLOC_33189.3bHLH family protein
MLOC_33189.4bHLH family protein
MLOC_33189.5bHLH family protein
MLOC_34429.1bHLH family protein
MLOC_35590.1bHLH family protein
MLOC_36345.1bHLH family protein
MLOC_36345.2bHLH family protein
MLOC_36345.3bHLH family protein
MLOC_36345.4bHLH family protein
MLOC_36351.1bHLH family protein
MLOC_36351.2bHLH family protein
MLOC_36423.2bHLH family protein
MLOC_36423.3bHLH family protein
MLOC_36423.4bHLH family protein
MLOC_36423.5bHLH family protein
MLOC_36423.6bHLH family protein
MLOC_37477.1bHLH family protein
MLOC_37477.3bHLH family protein
MLOC_37511.1bHLH family protein
MLOC_37511.2bHLH family protein
MLOC_37666.1bHLH family protein
MLOC_37666.2bHLH family protein
MLOC_37971.1bHLH family protein
MLOC_37971.2bHLH family protein
MLOC_37971.3bHLH family protein
MLOC_38425.1bHLH family protein
MLOC_38470.1bHLH family protein
MLOC_38470.2bHLH family protein
MLOC_38567.1bHLH family protein
MLOC_3915.1bHLH family protein
MLOC_40119.1bHLH family protein
MLOC_40535.1bHLH family protein
MLOC_42591.1bHLH family protein
MLOC_42946.1bHLH family protein
MLOC_43080.2bHLH family protein
MLOC_4332.1bHLH family protein
MLOC_43396.1bHLH family protein
MLOC_43438.1bHLH family protein
MLOC_43438.2bHLH family protein
MLOC_43888.1bHLH family protein
MLOC_43888.2bHLH family protein
MLOC_43888.3bHLH family protein
MLOC_44566.1bHLH family protein
MLOC_44654.2bHLH family protein
MLOC_44850.1bHLH family protein
MLOC_44850.2bHLH family protein
MLOC_45114.1bHLH family protein
MLOC_45114.2bHLH family protein
MLOC_45114.3bHLH family protein
MLOC_46407.1bHLH family protein
MLOC_46407.2bHLH family protein
MLOC_46407.3bHLH family protein
MLOC_49032.1bHLH family protein
MLOC_51361.1bHLH family protein
MLOC_51361.2bHLH family protein
MLOC_52192.1bHLH family protein
MLOC_52192.2bHLH family protein
MLOC_52192.3bHLH family protein
MLOC_54157.1bHLH family protein
MLOC_54435.1bHLH family protein
MLOC_55094.1bHLH family protein
MLOC_55768.1bHLH family protein
MLOC_55870.1bHLH family protein
MLOC_55870.2bHLH family protein
MLOC_55870.3bHLH family protein
MLOC_55964.1bHLH family protein
MLOC_55964.10bHLH family protein
MLOC_55964.11bHLH family protein
MLOC_55964.12bHLH family protein
MLOC_55964.13bHLH family protein
MLOC_55964.14bHLH family protein
MLOC_55964.16bHLH family protein
MLOC_55964.17bHLH family protein
MLOC_55964.2bHLH family protein
MLOC_55964.6bHLH family protein
MLOC_55964.7bHLH family protein
MLOC_55964.8bHLH family protein
MLOC_55964.9bHLH family protein
MLOC_56065.2bHLH family protein
MLOC_56117.1bHLH family protein
MLOC_56117.2bHLH family protein
MLOC_56117.3bHLH family protein
MLOC_56117.4bHLH family protein
MLOC_56117.5bHLH family protein
MLOC_56117.6bHLH family protein
MLOC_56117.7bHLH family protein
MLOC_56814.1bHLH family protein
MLOC_56814.2bHLH family protein
MLOC_56814.3bHLH family protein
MLOC_56814.4bHLH family protein
MLOC_5684.1bHLH family protein
MLOC_5684.2bHLH family protein
MLOC_5684.3bHLH family protein
MLOC_57076.2bHLH family protein
MLOC_57076.3bHLH family protein
MLOC_57076.4bHLH family protein
MLOC_57269.1bHLH family protein
MLOC_57269.2bHLH family protein
MLOC_57269.3bHLH family protein
MLOC_57269.4bHLH family protein
MLOC_57622.1bHLH family protein
MLOC_57622.2bHLH family protein
MLOC_57622.3bHLH family protein
MLOC_57622.4bHLH family protein
MLOC_57631.1bHLH family protein
MLOC_57631.2bHLH family protein
MLOC_58414.3bHLH family protein
MLOC_58414.4bHLH family protein
MLOC_58414.5bHLH family protein
MLOC_59503.1bHLH family protein
MLOC_59503.3bHLH family protein
MLOC_59503.5bHLH family protein
MLOC_59503.7bHLH family protein
MLOC_59503.8bHLH family protein
MLOC_59511.1bHLH family protein
MLOC_60270.1bHLH family protein
MLOC_60270.2bHLH family protein
MLOC_60270.3bHLH family protein
MLOC_60270.4bHLH family protein
MLOC_60270.7bHLH family protein
MLOC_60274.1bHLH family protein
MLOC_60274.2bHLH family protein
MLOC_60274.3bHLH family protein
MLOC_60274.4bHLH family protein
MLOC_60274.5bHLH family protein
MLOC_60274.6bHLH family protein
MLOC_60291.1bHLH family protein
MLOC_60300.2bHLH family protein
MLOC_60455.1bHLH family protein
MLOC_60455.2bHLH family protein
MLOC_62335.1bHLH family protein
MLOC_62335.2bHLH family protein
MLOC_62335.3bHLH family protein
MLOC_62335.4bHLH family protein
MLOC_62335.5bHLH family protein
MLOC_62335.8bHLH family protein
MLOC_62844.1bHLH family protein
MLOC_62844.2bHLH family protein
MLOC_62844.3bHLH family protein
MLOC_6315.1bHLH family protein
MLOC_63969.3bHLH family protein
MLOC_64018.1bHLH family protein
MLOC_64018.2bHLH family protein
MLOC_64018.3bHLH family protein
MLOC_64018.4bHLH family protein
MLOC_64018.5bHLH family protein
MLOC_64390.1bHLH family protein
MLOC_64390.3bHLH family protein
MLOC_64735.1bHLH family protein
MLOC_64735.2bHLH family protein
MLOC_65318.1bHLH family protein
MLOC_65318.2bHLH family protein
MLOC_65345.1bHLH family protein
MLOC_65463.1bHLH family protein
MLOC_65953.1bHLH family protein
MLOC_66385.1bHLH family protein
MLOC_66385.2bHLH family protein
MLOC_66841.1bHLH family protein
MLOC_66841.2bHLH family protein
MLOC_67053.1bHLH family protein
MLOC_6707.1bHLH family protein
MLOC_67091.1bHLH family protein
MLOC_67369.1bHLH family protein
MLOC_67369.2bHLH family protein
MLOC_67417.1bHLH family protein
MLOC_67417.2bHLH family protein
MLOC_67417.3bHLH family protein
MLOC_67483.1bHLH family protein
MLOC_67797.1bHLH family protein
MLOC_67797.2bHLH family protein
MLOC_67834.1bHLH family protein
MLOC_67834.2bHLH family protein
MLOC_67834.5bHLH family protein
MLOC_67937.1bHLH family protein
MLOC_67937.2bHLH family protein
MLOC_67972.1bHLH family protein
MLOC_67972.2bHLH family protein
MLOC_67972.3bHLH family protein
MLOC_68598.1bHLH family protein
MLOC_68598.2bHLH family protein
MLOC_68598.4bHLH family protein
MLOC_68896.1bHLH family protein
MLOC_68896.2bHLH family protein
MLOC_68896.3bHLH family protein
MLOC_68896.4bHLH family protein
MLOC_68896.5bHLH family protein
MLOC_6900.1bHLH family protein
MLOC_69121.2bHLH family protein
MLOC_69470.1bHLH family protein
MLOC_69470.2bHLH family protein
MLOC_70258.1bHLH family protein
MLOC_70258.2bHLH family protein
MLOC_70258.3bHLH family protein
MLOC_70409.1bHLH family protein
MLOC_70640.1bHLH family protein
MLOC_71056.1bHLH family protein
MLOC_71592.2bHLH family protein
MLOC_71592.3bHLH family protein
MLOC_71592.4bHLH family protein
MLOC_71592.5bHLH family protein
MLOC_71611.1bHLH family protein
MLOC_71611.2bHLH family protein
MLOC_72280.1bHLH family protein
MLOC_72614.1bHLH family protein
MLOC_72614.2bHLH family protein
MLOC_72614.4bHLH family protein
MLOC_72940.2bHLH family protein
MLOC_72940.3bHLH family protein
MLOC_72940.6bHLH family protein
MLOC_73706.1bHLH family protein
MLOC_73706.3bHLH family protein
MLOC_74022.1bHLH family protein
MLOC_74022.2bHLH family protein
MLOC_74170.1bHLH family protein
MLOC_74170.2bHLH family protein
MLOC_74394.1bHLH family protein
MLOC_74394.2bHLH family protein
MLOC_74977.2bHLH family protein
MLOC_74977.3bHLH family protein
MLOC_74977.5bHLH family protein
MLOC_76486.1bHLH family protein
MLOC_76805.1bHLH family protein
MLOC_76805.2bHLH family protein
MLOC_77331.1bHLH family protein
MLOC_77331.2bHLH family protein
MLOC_77331.3bHLH family protein
MLOC_77331.4bHLH family protein
MLOC_7883.1bHLH family protein
MLOC_7883.3bHLH family protein
MLOC_7883.4bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250