PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Hordeum vulgare
HD-ZIP Family
Species TF ID Description
MLOC_52115.1HD-ZIP family protein
MLOC_5668.1HD-ZIP family protein
MLOC_71555.2HD-ZIP family protein
MLOC_54921.2HD-ZIP family protein
MLOC_70350.1HD-ZIP family protein
MLOC_80844.1HD-ZIP family protein
MLOC_60848.1HD-ZIP family protein
MLOC_77955.2HD-ZIP family protein
MLOC_70350.2HD-ZIP family protein
MLOC_65462.2HD-ZIP family protein
MLOC_54441.1HD-ZIP family protein
MLOC_69710.1HD-ZIP family protein
MLOC_65462.1HD-ZIP family protein
MLOC_66350.2HD-ZIP family protein
MLOC_5727.1HD-ZIP family protein
MLOC_60848.4HD-ZIP family protein
MLOC_55339.1HD-ZIP family protein
MLOC_77488.1HD-ZIP family protein
MLOC_56648.2HD-ZIP family protein
MLOC_8033.1HD-ZIP family protein
MLOC_54921.1HD-ZIP family protein
MLOC_56648.1HD-ZIP family protein
MLOC_34121.1HD-ZIP family protein
MLOC_77955.4HD-ZIP family protein
MLOC_54441.2HD-ZIP family protein
MLOC_34121.2HD-ZIP family protein
MLOC_1969.1HD-ZIP family protein
MLOC_65829.1HD-ZIP family protein
MLOC_65829.2HD-ZIP family protein
MLOC_52316.1HD-ZIP family protein
MLOC_61420.1HD-ZIP family protein
MLOC_58644.2HD-ZIP family protein
MLOC_58644.1HD-ZIP family protein
MLOC_15014.2HD-ZIP family protein
MLOC_61603.2HD-ZIP family protein
MLOC_61603.3HD-ZIP family protein
MLOC_61603.4HD-ZIP family protein
MLOC_61603.1HD-ZIP family protein
MLOC_52077.1HD-ZIP family protein
MLOC_52077.2HD-ZIP family protein
MLOC_52077.3HD-ZIP family protein
MLOC_35104.1HD-ZIP family protein
MLOC_35104.2HD-ZIP family protein
MLOC_13375.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401