PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Glycine soja
MIKC_MADS Family
Species TF ID Description
KHM99070.1MIKC_MADS family protein
KHM99620.1MIKC_MADS family protein
KHN00205.1MIKC_MADS family protein
KHN00417.1MIKC_MADS family protein
KHN02780.1MIKC_MADS family protein
KHN03168.1MIKC_MADS family protein
KHN04103.1MIKC_MADS family protein
KHN04591.1MIKC_MADS family protein
KHN04595.1MIKC_MADS family protein
KHN04701.1MIKC_MADS family protein
KHN05163.1MIKC_MADS family protein
KHN06927.1MIKC_MADS family protein
KHN08262.1MIKC_MADS family protein
KHN08352.1MIKC_MADS family protein
KHN08355.1MIKC_MADS family protein
KHN09002.1MIKC_MADS family protein
KHN09738.1MIKC_MADS family protein
KHN11951.1MIKC_MADS family protein
KHN12377.1MIKC_MADS family protein
KHN12378.1MIKC_MADS family protein
KHN14511.1MIKC_MADS family protein
KHN15200.1MIKC_MADS family protein
KHN15201.1MIKC_MADS family protein
KHN15689.1MIKC_MADS family protein
KHN15694.1MIKC_MADS family protein
KHN16216.1MIKC_MADS family protein
KHN18105.1MIKC_MADS family protein
KHN18378.1MIKC_MADS family protein
KHN18381.1MIKC_MADS family protein
KHN19592.1MIKC_MADS family protein
KHN20547.1MIKC_MADS family protein
KHN22068.1MIKC_MADS family protein
KHN22206.1MIKC_MADS family protein
KHN23056.1MIKC_MADS family protein
KHN24051.1MIKC_MADS family protein
KHN28441.1MIKC_MADS family protein
KHN29421.1MIKC_MADS family protein
KHN29588.1MIKC_MADS family protein
KHN29767.1MIKC_MADS family protein
KHN29957.1MIKC_MADS family protein
KHN29958.1MIKC_MADS family protein
KHN30312.1MIKC_MADS family protein
KHN30313.1MIKC_MADS family protein
KHN31554.1MIKC_MADS family protein
KHN32441.1MIKC_MADS family protein
KHN33563.1MIKC_MADS family protein
KHN34444.1MIKC_MADS family protein
KHN34480.1MIKC_MADS family protein
KHN34831.1MIKC_MADS family protein
KHN34832.1MIKC_MADS family protein
KHN36061.1MIKC_MADS family protein
KHN37140.1MIKC_MADS family protein
KHN37768.1MIKC_MADS family protein
KHN37943.1MIKC_MADS family protein
KHN38307.1MIKC_MADS family protein
KHN38899.1MIKC_MADS family protein
KHN38979.1MIKC_MADS family protein
KHN41927.1MIKC_MADS family protein
KHN44300.1MIKC_MADS family protein
KHN44454.1MIKC_MADS family protein
KHN45898.1MIKC_MADS family protein
KHN46234.1MIKC_MADS family protein
KHN46260.1MIKC_MADS family protein
KHN46661.1MIKC_MADS family protein
KHN46985.1MIKC_MADS family protein
KHN47370.1MIKC_MADS family protein
KHN48036.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513