PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Glycine soja
HD-ZIP Family
Species TF ID Description
KHN23555.1HD-ZIP family protein
KHN47180.1HD-ZIP family protein
KHN08691.1HD-ZIP family protein
KHN32882.1HD-ZIP family protein
KHN01193.1HD-ZIP family protein
KHN28720.1HD-ZIP family protein
KHN01166.1HD-ZIP family protein
KHN31398.1HD-ZIP family protein
KHN44360.1HD-ZIP family protein
KHN06836.1HD-ZIP family protein
KHN45489.1HD-ZIP family protein
KHN41711.1HD-ZIP family protein
KHN29035.1HD-ZIP family protein
KHN11572.1HD-ZIP family protein
KHN19374.1HD-ZIP family protein
KHN08860.1HD-ZIP family protein
KHN13480.1HD-ZIP family protein
KHN06556.1HD-ZIP family protein
KHN35655.1HD-ZIP family protein
KHN48659.1HD-ZIP family protein
KHN18524.1HD-ZIP family protein
KHN13232.1HD-ZIP family protein
KHN13024.1HD-ZIP family protein
KHN11596.1HD-ZIP family protein
KHN13627.1HD-ZIP family protein
KHN42679.1HD-ZIP family protein
KHN44561.1HD-ZIP family protein
KHN45424.1HD-ZIP family protein
KHN01720.1HD-ZIP family protein
KHN34911.1HD-ZIP family protein
KHN36326.1HD-ZIP family protein
KHN47559.1HD-ZIP family protein
KHN19633.1HD-ZIP family protein
KHN19536.1HD-ZIP family protein
KHN23322.1HD-ZIP family protein
KHN17199.1HD-ZIP family protein
KHN06343.1HD-ZIP family protein
KHN18716.1HD-ZIP family protein
KHN37001.1HD-ZIP family protein
KHN15901.1HD-ZIP family protein
KHN36144.1HD-ZIP family protein
KHN48206.1HD-ZIP family protein
KHN35837.1HD-ZIP family protein
KHN45700.1HD-ZIP family protein
KHN24619.1HD-ZIP family protein
KHN22643.1HD-ZIP family protein
KHN42008.1HD-ZIP family protein
KHN41427.1HD-ZIP family protein
KHN29741.1HD-ZIP family protein
KHN00562.1HD-ZIP family protein
KHN17656.1HD-ZIP family protein
KHN27631.1HD-ZIP family protein
KHN34515.1HD-ZIP family protein
KHM98745.1HD-ZIP family protein
KHN21242.1HD-ZIP family protein
KHN47826.1HD-ZIP family protein
KHN32626.1HD-ZIP family protein
KHN36536.1HD-ZIP family protein
KHN04214.1HD-ZIP family protein
KHN41209.1HD-ZIP family protein
KHN44879.1HD-ZIP family protein
KHN35197.1HD-ZIP family protein
KHN30455.1HD-ZIP family protein
KHN39244.1HD-ZIP family protein
KHN05341.1HD-ZIP family protein
KHN21721.1HD-ZIP family protein
KHN15671.1HD-ZIP family protein
KHN31523.1HD-ZIP family protein
KHN23587.1HD-ZIP family protein
KHM99145.1HD-ZIP family protein
KHN24536.1HD-ZIP family protein
KHN39243.1HD-ZIP family protein
KHN48072.1HD-ZIP family protein
KHN18159.1HD-ZIP family protein
KHN10188.1HD-ZIP family protein
KHN00122.1HD-ZIP family protein
KHN14334.1HD-ZIP family protein
KHN10515.1HD-ZIP family protein
KHN06475.1HD-ZIP family protein
KHN22998.1HD-ZIP family protein
KHN15800.1HD-ZIP family protein
KHN02685.1HD-ZIP family protein
KHN38761.1HD-ZIP family protein
KHN05682.1HD-ZIP family protein
KHN38952.1HD-ZIP family protein
KHN04850.1HD-ZIP family protein
KHN23020.1HD-ZIP family protein
KHN14314.1HD-ZIP family protein
KHN28919.1HD-ZIP family protein
KHN23019.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401