PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Gossypium hirsutum
MIKC_MADS Family
Species TF ID Description
Gh_A01G1089MIKC_MADS family protein
Gh_A01G1608MIKC_MADS family protein
Gh_A02G0736MIKC_MADS family protein
Gh_A02G0780MIKC_MADS family protein
Gh_A02G1617MIKC_MADS family protein
Gh_A02G1782MIKC_MADS family protein
Gh_A03G0634MIKC_MADS family protein
Gh_A03G1085MIKC_MADS family protein
Gh_A03G1551MIKC_MADS family protein
Gh_A03G1563MIKC_MADS family protein
Gh_A03G2004MIKC_MADS family protein
Gh_A04G0934MIKC_MADS family protein
Gh_A04G1264MIKC_MADS family protein
Gh_A04G1265MIKC_MADS family protein
Gh_A05G2136MIKC_MADS family protein
Gh_A05G2191MIKC_MADS family protein
Gh_A05G2334MIKC_MADS family protein
Gh_A05G3267MIKC_MADS family protein
Gh_A06G0244MIKC_MADS family protein
Gh_A06G1875MIKC_MADS family protein
Gh_A07G0605MIKC_MADS family protein
Gh_A07G0722MIKC_MADS family protein
Gh_A07G1339MIKC_MADS family protein
Gh_A07G1615MIKC_MADS family protein
Gh_A08G1148MIKC_MADS family protein
Gh_A08G1275MIKC_MADS family protein
Gh_A09G2157MIKC_MADS family protein
Gh_A10G2220MIKC_MADS family protein
Gh_A10G2221MIKC_MADS family protein
Gh_A11G0077MIKC_MADS family protein
Gh_A11G0343MIKC_MADS family protein
Gh_A11G0462MIKC_MADS family protein
Gh_A11G0754MIKC_MADS family protein
Gh_A11G0755MIKC_MADS family protein
Gh_A12G0150MIKC_MADS family protein
Gh_A12G0570MIKC_MADS family protein
Gh_A12G0775MIKC_MADS family protein
Gh_A12G0910MIKC_MADS family protein
Gh_A12G0936MIKC_MADS family protein
Gh_A12G2048MIKC_MADS family protein
Gh_A13G0423MIKC_MADS family protein
Gh_A13G0425MIKC_MADS family protein
Gh_A13G0442MIKC_MADS family protein
Gh_A13G0524MIKC_MADS family protein
Gh_A13G0751MIKC_MADS family protein
Gh_A13G0981MIKC_MADS family protein
Gh_D02G0779MIKC_MADS family protein
Gh_D02G0829MIKC_MADS family protein
Gh_D02G0895MIKC_MADS family protein
Gh_D02G1311MIKC_MADS family protein
Gh_D02G1502MIKC_MADS family protein
Gh_D02G2012MIKC_MADS family protein
Gh_D03G0105MIKC_MADS family protein
Gh_D03G0626MIKC_MADS family protein
Gh_D03G0922MIKC_MADS family protein
Gh_D03G1493MIKC_MADS family protein
Gh_D04G0341MIKC_MADS family protein
Gh_D04G1451MIKC_MADS family protein
Gh_D04G1891MIKC_MADS family protein
Gh_D04G1892MIKC_MADS family protein
Gh_D05G2375MIKC_MADS family protein
Gh_D05G2452MIKC_MADS family protein
Gh_D05G2596MIKC_MADS family protein
Gh_D06G0245MIKC_MADS family protein
Gh_D06G0267MIKC_MADS family protein
Gh_D07G0671MIKC_MADS family protein
Gh_D07G0780MIKC_MADS family protein
Gh_D07G1448MIKC_MADS family protein
Gh_D07G1814MIKC_MADS family protein
Gh_D08G1430MIKC_MADS family protein
Gh_D09G0390MIKC_MADS family protein
Gh_D09G2362MIKC_MADS family protein
Gh_D10G0308MIKC_MADS family protein
Gh_D10G0309MIKC_MADS family protein
Gh_D11G0082MIKC_MADS family protein
Gh_D11G0400MIKC_MADS family protein
Gh_D11G0534MIKC_MADS family protein
Gh_D11G0882MIKC_MADS family protein
Gh_D11G0883MIKC_MADS family protein
Gh_D11G2216MIKC_MADS family protein
Gh_D11G3150MIKC_MADS family protein
Gh_D12G0156MIKC_MADS family protein
Gh_D12G0163MIKC_MADS family protein
Gh_D12G0585MIKC_MADS family protein
Gh_D12G0778MIKC_MADS family protein
Gh_D12G1000MIKC_MADS family protein
Gh_D12G1027MIKC_MADS family protein
Gh_D12G2226MIKC_MADS family protein
Gh_D13G0472MIKC_MADS family protein
Gh_D13G0489MIKC_MADS family protein
Gh_D13G0605MIKC_MADS family protein
Gh_D13G0877MIKC_MADS family protein
Gh_D13G0878MIKC_MADS family protein
Gh_D13G1226MIKC_MADS family protein
Gh_Sca004768G07MIKC_MADS family protein
Gh_Sca007246G01MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513