PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Gossypium hirsutum
M-type_MADS Family
Species TF ID Description
Gh_A01G1520M-type_MADS family protein
Gh_A03G0884M-type_MADS family protein
Gh_A03G1437M-type_MADS family protein
Gh_A03G1892M-type_MADS family protein
Gh_A04G1016M-type_MADS family protein
Gh_A04G1017M-type_MADS family protein
Gh_A04G1097M-type_MADS family protein
Gh_A04G1336M-type_MADS family protein
Gh_A04G1337M-type_MADS family protein
Gh_A04G1339M-type_MADS family protein
Gh_A05G1797M-type_MADS family protein
Gh_A05G2461M-type_MADS family protein
Gh_A05G2981M-type_MADS family protein
Gh_A06G0748M-type_MADS family protein
Gh_A06G1194M-type_MADS family protein
Gh_A07G0593M-type_MADS family protein
Gh_A08G1767M-type_MADS family protein
Gh_A08G2260M-type_MADS family protein
Gh_A09G1063M-type_MADS family protein
Gh_A09G1102M-type_MADS family protein
Gh_A09G1313M-type_MADS family protein
Gh_A09G1315M-type_MADS family protein
Gh_A09G1316M-type_MADS family protein
Gh_A10G0469M-type_MADS family protein
Gh_A10G1445M-type_MADS family protein
Gh_A11G1637M-type_MADS family protein
Gh_A11G1992M-type_MADS family protein
Gh_A11G2521M-type_MADS family protein
Gh_A12G0273M-type_MADS family protein
Gh_A12G0506M-type_MADS family protein
Gh_A12G0937M-type_MADS family protein
Gh_A12G1236M-type_MADS family protein
Gh_A12G1618M-type_MADS family protein
Gh_A13G0671M-type_MADS family protein
Gh_A13G2300M-type_MADS family protein
Gh_D01G1768M-type_MADS family protein
Gh_D01G1769M-type_MADS family protein
Gh_D02G1268M-type_MADS family protein
Gh_D02G1896M-type_MADS family protein
Gh_D02G2332M-type_MADS family protein
Gh_D03G0460M-type_MADS family protein
Gh_D04G0771M-type_MADS family protein
Gh_D04G1566M-type_MADS family protein
Gh_D04G1567M-type_MADS family protein
Gh_D04G1568M-type_MADS family protein
Gh_D05G1992M-type_MADS family protein
Gh_D05G2090M-type_MADS family protein
Gh_D05G2571M-type_MADS family protein
Gh_D05G2728M-type_MADS family protein
Gh_D05G3207M-type_MADS family protein
Gh_D05G3209M-type_MADS family protein
Gh_D05G3210M-type_MADS family protein
Gh_D05G3229M-type_MADS family protein
Gh_D06G0877M-type_MADS family protein
Gh_D06G0878M-type_MADS family protein
Gh_D06G1203M-type_MADS family protein
Gh_D06G1205M-type_MADS family protein
Gh_D06G1206M-type_MADS family protein
Gh_D06G1207M-type_MADS family protein
Gh_D06G1389M-type_MADS family protein
Gh_D06G1489M-type_MADS family protein
Gh_D07G0660M-type_MADS family protein
Gh_D08G2111M-type_MADS family protein
Gh_D08G2112M-type_MADS family protein
Gh_D08G2113M-type_MADS family protein
Gh_D08G2627M-type_MADS family protein
Gh_D09G1070M-type_MADS family protein
Gh_D09G1107M-type_MADS family protein
Gh_D09G1297M-type_MADS family protein
Gh_D09G1299M-type_MADS family protein
Gh_D10G0492M-type_MADS family protein
Gh_D10G1574M-type_MADS family protein
Gh_D11G1795M-type_MADS family protein
Gh_D11G1990M-type_MADS family protein
Gh_D11G3181M-type_MADS family protein
Gh_D11G3182M-type_MADS family protein
Gh_D12G0518M-type_MADS family protein
Gh_D12G1360M-type_MADS family protein
Gh_D12G1758M-type_MADS family protein
Gh_D12G2820M-type_MADS family protein
Gh_D13G0634M-type_MADS family protein
Gh_D13G0785M-type_MADS family protein
Gh_D13G0908M-type_MADS family protein
Gh_D13G1416M-type_MADS family protein
Gh_D13G1541M-type_MADS family protein
Gh_D13G1913M-type_MADS family protein
Gh_D13G1914M-type_MADS family protein
Gh_D13G1915M-type_MADS family protein
Gh_D13G1916M-type_MADS family protein
Gh_Sca004866G03M-type_MADS family protein
Gh_Sca005019G01M-type_MADS family protein
Gh_Sca018371G01M-type_MADS family protein
Gh_Sca074205G01M-type_MADS family protein
Gh_Sca087490G01M-type_MADS family protein
Gh_Sca228841G01M-type_MADS family protein
Gh_Sca259289G01M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513