PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Gossypium hirsutum
HD-ZIP Family
Species TF ID Description
Gh_D10G0847HD-ZIP family protein
Gh_Sca005979G01HD-ZIP family protein
Gh_D02G2405HD-ZIP family protein
Gh_A03G0861HD-ZIP family protein
Gh_D08G1807HD-ZIP family protein
Gh_D13G0756HD-ZIP family protein
Gh_A13G0639HD-ZIP family protein
Gh_Sca028226G01HD-ZIP family protein
Gh_D11G0266HD-ZIP family protein
Gh_A08G1509HD-ZIP family protein
Gh_A02G1237HD-ZIP family protein
Gh_D03G0374HD-ZIP family protein
Gh_A05G2636HD-ZIP family protein
Gh_A11G2970HD-ZIP family protein
Gh_D05G2926HD-ZIP family protein
Gh_D12G2139HD-ZIP family protein
Gh_A12G1960HD-ZIP family protein
Gh_A09G1204HD-ZIP family protein
Gh_D09G1210HD-ZIP family protein
Gh_A09G0195HD-ZIP family protein
Gh_A10G0774HD-ZIP family protein
Gh_D10G0992HD-ZIP family protein
Gh_A07G0585HD-ZIP family protein
Gh_D07G0654HD-ZIP family protein
Gh_D08G1112HD-ZIP family protein
Gh_A12G2639HD-ZIP family protein
Gh_Sca073981G01HD-ZIP family protein
Gh_A12G0871HD-ZIP family protein
Gh_D12G0953HD-ZIP family protein
Gh_A12G0771HD-ZIP family protein
Gh_D12G0780HD-ZIP family protein
Gh_A05G1913HD-ZIP family protein
Gh_D03G0292HD-ZIP family protein
Gh_A02G1428HD-ZIP family protein
Gh_D06G0289HD-ZIP family protein
Gh_D04G0859HD-ZIP family protein
Gh_A03G0571HD-ZIP family protein
Gh_D11G0809HD-ZIP family protein
Gh_A06G0266HD-ZIP family protein
Gh_D05G2148HD-ZIP family protein
Gh_D12G1725HD-ZIP family protein
Gh_A11G0692HD-ZIP family protein
Gh_A11G0690HD-ZIP family protein
Gh_A12G0726HD-ZIP family protein
Gh_A11G3156HD-ZIP family protein
Gh_D11G0807HD-ZIP family protein
Gh_D08G1109HD-ZIP family protein
Gh_D11G0526HD-ZIP family protein
Gh_A11G0454HD-ZIP family protein
Gh_D11G2639HD-ZIP family protein
Gh_A08G0909HD-ZIP family protein
Gh_D04G0457HD-ZIP family protein
Gh_D01G1219HD-ZIP family protein
Gh_A07G1966HD-ZIP family protein
Gh_D11G2140HD-ZIP family protein
Gh_A11G1855HD-ZIP family protein
Gh_D01G2042HD-ZIP family protein
Gh_A11G0693HD-ZIP family protein
Gh_A01G1616HD-ZIP family protein
Gh_D07G2184HD-ZIP family protein
Gh_D02G1724HD-ZIP family protein
Gh_A01G1130HD-ZIP family protein
Gh_D02G0871HD-ZIP family protein
Gh_D11G1052HD-ZIP family protein
Gh_A03G1284HD-ZIP family protein
Gh_A01G1026HD-ZIP family protein
Gh_A12G1033HD-ZIP family protein
Gh_D11G0473HD-ZIP family protein
Gh_A02G0823HD-ZIP family protein
Gh_D12G1152HD-ZIP family protein
Gh_A01G1802HD-ZIP family protein
Gh_A11G0906HD-ZIP family protein
Gh_A01G1801HD-ZIP family protein
Gh_A02G1563HD-ZIP family protein
Gh_D11G0153HD-ZIP family protein
Gh_A11G0139HD-ZIP family protein
Gh_A08G0907HD-ZIP family protein
Gh_D01G1080HD-ZIP family protein
Gh_D11G1879HD-ZIP family protein
Gh_D01G1470HD-ZIP family protein
Gh_A11G0410HD-ZIP family protein
Gh_A11G1721HD-ZIP family protein
Gh_Sca004718G01HD-ZIP family protein
Gh_D03G0161HD-ZIP family protein
Gh_A07G1237HD-ZIP family protein
Gh_D07G1346HD-ZIP family protein
Gh_A05G2682HD-ZIP family protein
Gh_D05G2980HD-ZIP family protein
Gh_D03G0850HD-ZIP family protein
Gh_D12G2350HD-ZIP family protein
Gh_D08G0905HD-ZIP family protein
Gh_A12G2171HD-ZIP family protein
Gh_D09G1239HD-ZIP family protein
Gh_D10G0770HD-ZIP family protein
Gh_D01G1287HD-ZIP family protein
Gh_D12G0450HD-ZIP family protein
Gh_D01G0446HD-ZIP family protein
Gh_D01G0447HD-ZIP family protein
Gh_D08G1853HD-ZIP family protein
Gh_A01G0439HD-ZIP family protein
Gh_A04G0563HD-ZIP family protein
Gh_A11G1037HD-ZIP family protein
Gh_D13G1514HD-ZIP family protein
Gh_D01G1844HD-ZIP family protein
Gh_A04G1376HD-ZIP family protein
Gh_D05G2054HD-ZIP family protein
Gh_A05G1856HD-ZIP family protein
Gh_A05G3845HD-ZIP family protein
Gh_D05G1246HD-ZIP family protein
Gh_A06G1283HD-ZIP family protein
Gh_D06G1607HD-ZIP family protein
Gh_D12G1563HD-ZIP family protein
Gh_D02G1338HD-ZIP family protein
Gh_A11G0777HD-ZIP family protein
Gh_D13G2528HD-ZIP family protein
Gh_A03G0957HD-ZIP family protein
Gh_D11G0906HD-ZIP family protein
Gh_A13G0777HD-ZIP family protein
Gh_A12G1446HD-ZIP family protein
Gh_A10G0143HD-ZIP family protein
Gh_D10G0146HD-ZIP family protein
Gh_D12G1049HD-ZIP family protein
Gh_A07G1332HD-ZIP family protein
Gh_A12G2601HD-ZIP family protein
Gh_D07G1441HD-ZIP family protein
Gh_A07G0163HD-ZIP family protein
Gh_D07G0220HD-ZIP family protein
Gh_D05G0479HD-ZIP family protein
Gh_A05G1085HD-ZIP family protein
Gh_D05G1263HD-ZIP family protein
Gh_A06G0833HD-ZIP family protein
Gh_D06G0966HD-ZIP family protein
Gh_A12G2462HD-ZIP family protein
Gh_D12G2590HD-ZIP family protein
Gh_D10G0038HD-ZIP family protein
Gh_A10G0035HD-ZIP family protein
Gh_A09G0391HD-ZIP family protein
Gh_Sca007830G01HD-ZIP family protein
Gh_A05G0364HD-ZIP family protein
Gh_D08G2109HD-ZIP family protein
Gh_D05G0975HD-ZIP family protein
Gh_A08G2453HD-ZIP family protein
Gh_A13G2011HD-ZIP family protein
Gh_A08G1765HD-ZIP family protein
Gh_D03G1290HD-ZIP family protein
Gh_A05G0892HD-ZIP family protein
Gh_D13G2409HD-ZIP family protein
Gh_A03G0276HD-ZIP family protein
Gh_D03G1654HD-ZIP family protein
Gh_D03G1655HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401