PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Genlisea aurea
HD-ZIP Family
Species TF ID Description
EPS58259.1HD-ZIP family protein
EPS66266.1HD-ZIP family protein
EPS64994.1HD-ZIP family protein
EPS69830.1HD-ZIP family protein
EPS57454.1HD-ZIP family protein
EPS68550.1HD-ZIP family protein
EPS64070.1HD-ZIP family protein
EPS73634.1HD-ZIP family protein
EPS69011.1HD-ZIP family protein
EPS64189.1HD-ZIP family protein
EPS74326.1HD-ZIP family protein
EPS68404.1HD-ZIP family protein
EPS61383.1HD-ZIP family protein
EPS57803.1HD-ZIP family protein
EPS60880.1HD-ZIP family protein
EPS59260.1HD-ZIP family protein
EPS62262.1HD-ZIP family protein
EPS64148.1HD-ZIP family protein
EPS73415.1HD-ZIP family protein
EPS59222.1HD-ZIP family protein
EPS59764.1HD-ZIP family protein
EPS72936.1HD-ZIP family protein
EPS72090.1HD-ZIP family protein
EPS72360.1HD-ZIP family protein
EPS62656.1HD-ZIP family protein
EPS59283.1HD-ZIP family protein
EPS57974.1HD-ZIP family protein
EPS70991.1HD-ZIP family protein
EPS70568.1HD-ZIP family protein
EPS57394.1HD-ZIP family protein
EPS58685.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401