Plant Transcription Factor Database
Previous version: v1.0, v2.0, v3.0
Gossypium arboreum
ZF-HD Family
Species TF ID Description
Cotton_A_01606_BGI-A2_v1.0ZF-HD family protein
Cotton_A_02016_BGI-A2_v1.0ZF-HD family protein
Cotton_A_02051_BGI-A2_v1.0ZF-HD family protein
Cotton_A_02798_BGI-A2_v1.0ZF-HD family protein
Cotton_A_05931_BGI-A2_v1.0ZF-HD family protein
Cotton_A_09279_BGI-A2_v1.0ZF-HD family protein
Cotton_A_11203_BGI-A2_v1.0ZF-HD family protein
Cotton_A_13064_BGI-A2_v1.0ZF-HD family protein
Cotton_A_13766_BGI-A2_v1.0ZF-HD family protein
Cotton_A_14653_BGI-A2_v1.0ZF-HD family protein
Cotton_A_17599_BGI-A2_v1.0ZF-HD family protein
Cotton_A_19854_BGI-A2_v1.0ZF-HD family protein
Cotton_A_27582_BGI-A2_v1.0ZF-HD family protein
Cotton_A_27654_BGI-A2_v1.0ZF-HD family protein
Cotton_A_30607_BGI-A2_v1.0ZF-HD family protein
Cotton_A_30610_BGI-A2_v1.0ZF-HD family protein
Cotton_A_31397_BGI-A2_v1.0ZF-HD family protein
Cotton_A_34763_BGI-A2_v1.0ZF-HD family protein
Cotton_A_36026_BGI-A2_v1.0ZF-HD family protein
Cotton_A_37150_BGI-A2_v1.0ZF-HD family protein
Cotton_A_38394_BGI-A2_v1.0ZF-HD family protein
Cotton_A_39305_BGI-A2_v1.0ZF-HD family protein
ZF-HD Family Introduction

This group of sequences described by a 54-residue domain found in the N-terminal region of plant proteins, the vast majority of which contain a ZF-HD class homeobox domain toward the C terminus. The region between the two domains typically is rich in low complexity sequence. The companion ZF-HD homeobox domain is described in INTERPRO:IPR006455.

A one-hybrid screen resulted in the cloning of four different members of a novel class of plant homeodomain proteins, which are most likely involved in the mesophyll-specific expression of the C4 PEPCase gene in C4 species of the genus Flaveria. Inspection of the homeodomains of the four proteins reveals that they share many common features with homeodomains described so far, but there are also significant differences. Interestingly, this class of homeodomain proteins occurs also in Arabidopsis thaliana and other C3 plants. One-hybrid experiments as well as in vitro DNA binding studies confirmed that these novel homeodomain proteins specifically interact with the proximal region of the C4 PEPCase (C4 phosphoenolpyruvate carboxylase) gene. The N-terminal domains of the homeodomain proteins contain highly conserved sequence motifs. Two-hybrid experiments show that these motifs are sufficient to confer homo- or heterodimer formation between the proteins. Mutagenesis of conserved cysteine residues within the dimerization domain indicates that these residues are essential for dimer formation. Therefore, we designate this novel class of homeobox proteins ZF-HD, for zinc finger homeodomain protein. Our data suggest that the ZF-HD class of homeodomain proteins may be involved in the establishment of the characteristic expression pattern of the C4 PEPCase gene.

Windhovel A, Hein I, Dabrowa R, Stockhaus J.
Characterization of a novel class of plant homeodomain proteins that bind to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia.
Plant Mol Biol. 2001 Jan;45(2):201-14.
PMID: 11289511