PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Gossypium arboreum
MIKC_MADS Family
Species TF ID Description
Cotton_A_01579_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_01937_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_02783_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_03373_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_03985_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_04560_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_06622_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_07550_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_08842_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_09654_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_10847_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_10849_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_10950_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_10951_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_11745_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_11746_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_14104_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_15815_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_17221_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_17354_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_18749_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_20826_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_22910_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_22943_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_24135_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_24476_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_25477_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_25835_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_26485_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_28384_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_29164_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_29978_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_30212_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_32186_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_33618_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_34365_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_34844_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_35903_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_36537_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_37831_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_38191_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_39936_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_40147_BGI-A2_v1.0MIKC_MADS family protein
Cotton_A_40148_BGI-A2_v1.0MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513