PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Gossypium arboreum
M-type_MADS Family
Species TF ID Description
Cotton_A_00551_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_01814_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_01866_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_01867_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_02066_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_03202_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_05132_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_05133_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_06383_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_08557_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_08703_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_08824_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_08944_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_10100_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_11433_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_11922_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_13400_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_14428_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_14567_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_14817_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_14818_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_16797_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_16798_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_17196_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_17199_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_17264_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_19334_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_19498_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_20837_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_21613_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_21615_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_21616_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_21857_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_21862_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_21961_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_22108_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_23916_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_24082_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_24831_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_25833_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_26903_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_27146_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_27666_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_28206_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_28403_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_28416_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_28455_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_29132_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_29349_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_29352_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_29353_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_29367_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_29771_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_34715_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_35030_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_35031_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_37076_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_37874_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_38285_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_38716_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_39419_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_39420_BGI-A2_v1.0M-type_MADS family protein
Cotton_A_40253_BGI-A2_v1.0M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513