PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Fragaria vesca
bHLH Family
Species TF ID Description
mrna00545.1-v1.0-hybridbHLH family protein
mrna00554.1-v1.0-hybridbHLH family protein
mrna00631.1-v1.0-hybridbHLH family protein
mrna00752.1-v1.0-hybridbHLH family protein
mrna00901.1-v1.0-hybridbHLH family protein
mrna01068.1-v1.0-hybridbHLH family protein
mrna01894.1-v1.0-hybridbHLH family protein
mrna02199.1-v1.0-hybridbHLH family protein
mrna02381.1-v1.0-hybridbHLH family protein
mrna02560.1-v1.0-hybridbHLH family protein
mrna02629.1-v1.0-hybridbHLH family protein
mrna03259.1-v1.0-hybridbHLH family protein
mrna03303.1-v1.0-hybridbHLH family protein
mrna03678.1-v1.0-hybridbHLH family protein
mrna03713.1-v1.0-hybridbHLH family protein
mrna03879.1-v1.0-hybridbHLH family protein
mrna04513.1-v1.0-hybridbHLH family protein
mrna04534.1-v1.0-hybridbHLH family protein
mrna05560.1-v1.0-hybridbHLH family protein
mrna05610.1-v1.0-hybridbHLH family protein
mrna05612.1-v1.0-hybridbHLH family protein
mrna06093.1-v1.0-hybridbHLH family protein
mrna06435.1-v1.0-hybridbHLH family protein
mrna06448.1-v1.0-hybridbHLH family protein
mrna07355.1-v1.0-hybridbHLH family protein
mrna07391.1-v1.0-hybridbHLH family protein
mrna08188.1-v1.0-hybridbHLH family protein
mrna08231.1-v1.0-hybridbHLH family protein
mrna08411.1-v1.0-hybridbHLH family protein
mrna09115.1-v1.0-hybridbHLH family protein
mrna09125.1-v1.0-hybridbHLH family protein
mrna09222.1-v1.0-hybridbHLH family protein
mrna09544.1-v1.0-hybridbHLH family protein
mrna10062.1-v1.0-hybridbHLH family protein
mrna10203.1-v1.0-hybridbHLH family protein
mrna10501.1-v1.0-hybridbHLH family protein
mrna11436.1-v1.0-hybridbHLH family protein
mrna11847.1-v1.0-hybridbHLH family protein
mrna12030.1-v1.0-hybridbHLH family protein
mrna12191.1-v1.0-hybridbHLH family protein
mrna12658.1-v1.0-hybridbHLH family protein
mrna12905.1-v1.0-hybridbHLH family protein
mrna12958.1-v1.0-hybridbHLH family protein
mrna13109.1-v1.0-hybridbHLH family protein
mrna13364.1-v1.0-hybridbHLH family protein
mrna13365.1-v1.0-hybridbHLH family protein
mrna13480.1-v1.0-hybridbHLH family protein
mrna13705.1-v1.0-hybridbHLH family protein
mrna14427.1-v1.0-hybridbHLH family protein
mrna14608.1-v1.0-hybridbHLH family protein
mrna14814.1-v1.0-hybridbHLH family protein
mrna15187.1-v1.0-hybridbHLH family protein
mrna16221.1-v1.0-hybridbHLH family protein
mrna16564.1-v1.0-hybridbHLH family protein
mrna16871.1-v1.0-hybridbHLH family protein
mrna17273.1-v1.0-hybridbHLH family protein
mrna17430.1-v1.0-hybridbHLH family protein
mrna17723.1-v1.0-hybridbHLH family protein
mrna17881.1-v1.0-hybridbHLH family protein
mrna17937.1-v1.0-hybridbHLH family protein
mrna18542.1-v1.0-hybridbHLH family protein
mrna18608.1-v1.0-hybridbHLH family protein
mrna18651.1-v1.0-hybridbHLH family protein
mrna18888.1-v1.0-hybridbHLH family protein
mrna19143.1-v1.0-hybridbHLH family protein
mrna19321.1-v1.0-hybridbHLH family protein
mrna20146.1-v1.0-hybridbHLH family protein
mrna20622.1-v1.0-hybridbHLH family protein
mrna20797.1-v1.0-hybridbHLH family protein
mrna21000.1-v1.0-hybridbHLH family protein
mrna21440.1-v1.0-hybridbHLH family protein
mrna22289.1-v1.0-hybridbHLH family protein
mrna22490.1-v1.0-hybridbHLH family protein
mrna22861.1-v1.0-hybridbHLH family protein
mrna22897.1-v1.0-hybridbHLH family protein
mrna22963.1-v1.0-hybridbHLH family protein
mrna23715.1-v1.0-hybridbHLH family protein
mrna23716.1-v1.0-hybridbHLH family protein
mrna23819.1-v1.0-hybridbHLH family protein
mrna23830.1-v1.0-hybridbHLH family protein
mrna23884.1-v1.0-hybridbHLH family protein
mrna24577.1-v1.0-hybridbHLH family protein
mrna24607.1-v1.0-hybridbHLH family protein
mrna24608.1-v1.0-hybridbHLH family protein
mrna24654.1-v1.0-hybridbHLH family protein
mrna25151.1-v1.0-hybridbHLH family protein
mrna25273.1-v1.0-hybridbHLH family protein
mrna25546.1-v1.0-hybridbHLH family protein
mrna25554.1-v1.0-hybridbHLH family protein
mrna25555.1-v1.0-hybridbHLH family protein
mrna25973.1-v1.0-hybridbHLH family protein
mrna25979.1-v1.0-hybridbHLH family protein
mrna25984.1-v1.0-hybridbHLH family protein
mrna26073.1-v1.0-hybridbHLH family protein
mrna26139.1-v1.0-hybridbHLH family protein
mrna26696.1-v1.0-hybridbHLH family protein
mrna26880.1-v1.0-hybridbHLH family protein
mrna26895.1-v1.0-hybridbHLH family protein
mrna26967.1-v1.0-hybridbHLH family protein
mrna27422.1-v1.0-hybridbHLH family protein
mrna27827.1-v1.0-hybridbHLH family protein
mrna27840.1-v1.0-hybridbHLH family protein
mrna28320.1-v1.0-hybridbHLH family protein
mrna28785.1-v1.0-hybridbHLH family protein
mrna29828.1-v1.0-hybridbHLH family protein
mrna30478.1-v1.0-hybridbHLH family protein
mrna30665.1-v1.0-hybridbHLH family protein
mrna30667.1-v1.0-hybridbHLH family protein
mrna32171.1-v1.0-hybridbHLH family protein
mrna32346.1-v1.0-hybridbHLH family protein
mrna32494.1-v1.0-hybridbHLH family protein
mrna32536.1-v1.0-hybridbHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250