PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Fragaria x ananassa
HD-ZIP Family
Species TF ID Description
FANhyb_rscf00000104.1.g00008.1HD-ZIP family protein
FANhyb_icon00021958_a.1.g00001.1HD-ZIP family protein
FANhyb_rscf00000319.1.g00005.1HD-ZIP family protein
FANhyb_rscf00005620.1.g00001.1HD-ZIP family protein
FANhyb_rscf00004820.1.g00001.1HD-ZIP family protein
FANhyb_rscf00000331.1.g00001.1HD-ZIP family protein
FANhyb_rscf00001576.1.g00001.1HD-ZIP family protein
FANhyb_rscf00003049.1.g00001.1HD-ZIP family protein
FANhyb_rscf00000666.1.g00008.1HD-ZIP family protein
FANhyb_rscf00000594.1.g00003.1HD-ZIP family protein
FANhyb_rscf00001544.1.g00001.1HD-ZIP family protein
FANhyb_rscf00000084.1.g00007.1HD-ZIP family protein
FANhyb_icon00000411_a.1.g00001.1HD-ZIP family protein
FANhyb_rscf00000004.1.g00006.1HD-ZIP family protein
FANhyb_icon00011018_a.1.g00001.1HD-ZIP family protein
FANhyb_rscf00000232.1.g00002.1HD-ZIP family protein
FANhyb_rscf00000173.1.g00004.1HD-ZIP family protein
FANhyb_rscf00000020.1.g00010.1HD-ZIP family protein
FANhyb_rscf00000452.1.g00006.1HD-ZIP family protein
FANhyb_rscf00000078.1.g00007.1HD-ZIP family protein
FANhyb_rscf00000005.1.g00044.1HD-ZIP family protein
FANhyb_rscf00000015.1.g00005.1HD-ZIP family protein
FANhyb_rscf00001233.1.g00002.1HD-ZIP family protein
FANhyb_rscf00001205.1.g00002.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401