PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Eragrostis tef
MIKC_MADS Family
Species TF ID Description
462850820MIKC_MADS family protein
462853709MIKC_MADS family protein
462855964MIKC_MADS family protein
462858582MIKC_MADS family protein
462858624MIKC_MADS family protein
462861228MIKC_MADS family protein
462861340MIKC_MADS family protein
462865445MIKC_MADS family protein
462867737MIKC_MADS family protein
462871932MIKC_MADS family protein
462874353MIKC_MADS family protein
462876498MIKC_MADS family protein
462876904MIKC_MADS family protein
462876955MIKC_MADS family protein
462879964MIKC_MADS family protein
462880188MIKC_MADS family protein
462881795MIKC_MADS family protein
462884813MIKC_MADS family protein
462888313MIKC_MADS family protein
462889032MIKC_MADS family protein
462889112MIKC_MADS family protein
462893163MIKC_MADS family protein
462894627MIKC_MADS family protein
462896542MIKC_MADS family protein
462897598MIKC_MADS family protein
462897739MIKC_MADS family protein
462898146MIKC_MADS family protein
462898247MIKC_MADS family protein
462898916MIKC_MADS family protein
462900222MIKC_MADS family protein
462900732MIKC_MADS family protein
462900835MIKC_MADS family protein
462900874MIKC_MADS family protein
462903638MIKC_MADS family protein
462906066MIKC_MADS family protein
462913130MIKC_MADS family protein
462915264MIKC_MADS family protein
462916228MIKC_MADS family protein
462917456MIKC_MADS family protein
462919771MIKC_MADS family protein
462921669MIKC_MADS family protein
462927009MIKC_MADS family protein
462927341MIKC_MADS family protein
462928565MIKC_MADS family protein
462928914MIKC_MADS family protein
462939980MIKC_MADS family protein
462941473MIKC_MADS family protein
462950675MIKC_MADS family protein
462951306MIKC_MADS family protein
462960925MIKC_MADS family protein
462960979MIKC_MADS family protein
462968406MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513