PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Eragrostis tef
HD-ZIP Family
Species TF ID Description
462891374HD-ZIP family protein
462966519HD-ZIP family protein
462956324HD-ZIP family protein
462957694HD-ZIP family protein
462855850HD-ZIP family protein
462945137HD-ZIP family protein
462907733HD-ZIP family protein
462894813HD-ZIP family protein
462943849HD-ZIP family protein
462882144HD-ZIP family protein
462939059HD-ZIP family protein
462909522HD-ZIP family protein
462947657HD-ZIP family protein
462958540HD-ZIP family protein
462915162HD-ZIP family protein
462873455HD-ZIP family protein
462962815HD-ZIP family protein
462962809HD-ZIP family protein
462884619HD-ZIP family protein
462934812HD-ZIP family protein
462928772HD-ZIP family protein
462934815HD-ZIP family protein
462933074HD-ZIP family protein
462851818HD-ZIP family protein
462846454HD-ZIP family protein
462943539HD-ZIP family protein
462907574HD-ZIP family protein
462938539HD-ZIP family protein
462871422HD-ZIP family protein
462916357HD-ZIP family protein
462844979HD-ZIP family protein
462873084HD-ZIP family protein
462898925HD-ZIP family protein
462908070HD-ZIP family protein
462926787HD-ZIP family protein
462958393HD-ZIP family protein
462883939HD-ZIP family protein
462954788HD-ZIP family protein
462903426HD-ZIP family protein
462952195HD-ZIP family protein
462856208HD-ZIP family protein
462900811HD-ZIP family protein
462878264HD-ZIP family protein
462955627HD-ZIP family protein
462933953HD-ZIP family protein
462868679HD-ZIP family protein
462849005HD-ZIP family protein
462852433HD-ZIP family protein
462873836HD-ZIP family protein
462923282HD-ZIP family protein
462880431HD-ZIP family protein
462946074HD-ZIP family protein
462934595HD-ZIP family protein
462929967HD-ZIP family protein
462850151HD-ZIP family protein
462872890HD-ZIP family protein
462901099HD-ZIP family protein
462858910HD-ZIP family protein
462942416HD-ZIP family protein
462954451HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401