PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Eutrema salsugineum
bHLH Family
Species TF ID Description
Thhalv10000220mbHLH family protein
Thhalv10000251mbHLH family protein
Thhalv10000426mbHLH family protein
Thhalv10000494mbHLH family protein
Thhalv10000808mbHLH family protein
Thhalv10000853mbHLH family protein
Thhalv10000961mbHLH family protein
Thhalv10001374mbHLH family protein
Thhalv10001803mbHLH family protein
Thhalv10001974mbHLH family protein
Thhalv10002558mbHLH family protein
Thhalv10002578mbHLH family protein
Thhalv10002586mbHLH family protein
Thhalv10002990mbHLH family protein
Thhalv10003353mbHLH family protein
Thhalv10003393mbHLH family protein
Thhalv10004031mbHLH family protein
Thhalv10004059mbHLH family protein
Thhalv10004458mbHLH family protein
Thhalv10004524mbHLH family protein
Thhalv10004732mbHLH family protein
Thhalv10004734mbHLH family protein
Thhalv10004772mbHLH family protein
Thhalv10004846mbHLH family protein
Thhalv10004889mbHLH family protein
Thhalv10005197mbHLH family protein
Thhalv10005234mbHLH family protein
Thhalv10005929mbHLH family protein
Thhalv10005941mbHLH family protein
Thhalv10005953mbHLH family protein
Thhalv10006040mbHLH family protein
Thhalv10006045mbHLH family protein
Thhalv10006189mbHLH family protein
Thhalv10006191mbHLH family protein
Thhalv10006385mbHLH family protein
Thhalv10006410mbHLH family protein
Thhalv10006491mbHLH family protein
Thhalv10007075mbHLH family protein
Thhalv10007139mbHLH family protein
Thhalv10007343mbHLH family protein
Thhalv10007566mbHLH family protein
Thhalv10007594mbHLH family protein
Thhalv10007639mbHLH family protein
Thhalv10007669mbHLH family protein
Thhalv10007696mbHLH family protein
Thhalv10007800mbHLH family protein
Thhalv10008002mbHLH family protein
Thhalv10008050mbHLH family protein
Thhalv10008279mbHLH family protein
Thhalv10008306mbHLH family protein
Thhalv10008396mbHLH family protein
Thhalv10008474mbHLH family protein
Thhalv10008517mbHLH family protein
Thhalv10008699mbHLH family protein
Thhalv10009016mbHLH family protein
Thhalv10009197mbHLH family protein
Thhalv10009765mbHLH family protein
Thhalv10009819mbHLH family protein
Thhalv10009836mbHLH family protein
Thhalv10009862mbHLH family protein
Thhalv10009875mbHLH family protein
Thhalv10009922mbHLH family protein
Thhalv10009992mbHLH family protein
Thhalv10010670mbHLH family protein
Thhalv10010858mbHLH family protein
Thhalv10011068mbHLH family protein
Thhalv10011463mbHLH family protein
Thhalv10011752mbHLH family protein
Thhalv10012185mbHLH family protein
Thhalv10012562mbHLH family protein
Thhalv10013181mbHLH family protein
Thhalv10013360mbHLH family protein
Thhalv10013623mbHLH family protein
Thhalv10013877mbHLH family protein
Thhalv10014212mbHLH family protein
Thhalv10014239mbHLH family protein
Thhalv10014242mbHLH family protein
Thhalv10014371mbHLH family protein
Thhalv10014506mbHLH family protein
Thhalv10014564mbHLH family protein
Thhalv10014694mbHLH family protein
Thhalv10015131mbHLH family protein
Thhalv10015297mbHLH family protein
Thhalv10015330mbHLH family protein
Thhalv10016038mbHLH family protein
Thhalv10016331mbHLH family protein
Thhalv10016616mbHLH family protein
Thhalv10016715mbHLH family protein
Thhalv10016847mbHLH family protein
Thhalv10016957mbHLH family protein
Thhalv10016998mbHLH family protein
Thhalv10017007mbHLH family protein
Thhalv10017126mbHLH family protein
Thhalv10017167mbHLH family protein
Thhalv10017421mbHLH family protein
Thhalv10017520mbHLH family protein
Thhalv10017546mbHLH family protein
Thhalv10017751mbHLH family protein
Thhalv10017830mbHLH family protein
Thhalv10017908mbHLH family protein
Thhalv10017944mbHLH family protein
Thhalv10018444mbHLH family protein
Thhalv10018758mbHLH family protein
Thhalv10018867mbHLH family protein
Thhalv10018889mbHLH family protein
Thhalv10018898mbHLH family protein
Thhalv10018927mbHLH family protein
Thhalv10019010mbHLH family protein
Thhalv10019063mbHLH family protein
Thhalv10019164mbHLH family protein
Thhalv10019175mbHLH family protein
Thhalv10019637mbHLH family protein
Thhalv10019683mbHLH family protein
Thhalv10020666mbHLH family protein
Thhalv10020729mbHLH family protein
Thhalv10021177mbHLH family protein
Thhalv10021235mbHLH family protein
Thhalv10021271mbHLH family protein
Thhalv10021282mbHLH family protein
Thhalv10021324mbHLH family protein
Thhalv10022251mbHLH family protein
Thhalv10022273mbHLH family protein
Thhalv10022620mbHLH family protein
Thhalv10022772mbHLH family protein
Thhalv10023356mbHLH family protein
Thhalv10023433mbHLH family protein
Thhalv10023487mbHLH family protein
Thhalv10023490mbHLH family protein
Thhalv10023630mbHLH family protein
Thhalv10023637mbHLH family protein
Thhalv10023643mbHLH family protein
Thhalv10023682mbHLH family protein
Thhalv10023982mbHLH family protein
Thhalv10023998mbHLH family protein
Thhalv10024688mbHLH family protein
Thhalv10025122mbHLH family protein
Thhalv10025359mbHLH family protein
Thhalv10025554mbHLH family protein
Thhalv10025656mbHLH family protein
Thhalv10025715mbHLH family protein
Thhalv10025748mbHLH family protein
Thhalv10025750mbHLH family protein
Thhalv10025763mbHLH family protein
Thhalv10025811mbHLH family protein
Thhalv10025820mbHLH family protein
Thhalv10025889mbHLH family protein
Thhalv10025899mbHLH family protein
Thhalv10025927mbHLH family protein
Thhalv10025995mbHLH family protein
Thhalv10026039mbHLH family protein
Thhalv10026322mbHLH family protein
Thhalv10026341mbHLH family protein
Thhalv10026786mbHLH family protein
Thhalv10027186mbHLH family protein
Thhalv10027332mbHLH family protein
Thhalv10027500mbHLH family protein
Thhalv10027549mbHLH family protein
Thhalv10027582mbHLH family protein
Thhalv10027709mbHLH family protein
Thhalv10027863mbHLH family protein
Thhalv10028074mbHLH family protein
Thhalv10028239mbHLH family protein
Thhalv10028584mbHLH family protein
Thhalv10028687mbHLH family protein
Thhalv10028710mbHLH family protein
Thhalv10028815mbHLH family protein
Thhalv10028821mbHLH family protein
Thhalv10028824mbHLH family protein
Thhalv10028883mbHLH family protein
Thhalv10028884mbHLH family protein
Thhalv10029319mbHLH family protein
Thhalv10029523mbHLH family protein
Thhalv10029526mbHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250