PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Eutrema salsugineum
HD-ZIP Family
Species TF ID Description
Thhalv10018944mHD-ZIP family protein
Thhalv10022235mHD-ZIP family protein
Thhalv10004645mHD-ZIP family protein
Thhalv10000259mHD-ZIP family protein
Thhalv10025832mHD-ZIP family protein
Thhalv10014027mHD-ZIP family protein
Thhalv10014157mHD-ZIP family protein
Thhalv10025903mHD-ZIP family protein
Thhalv10001549mHD-ZIP family protein
Thhalv10021334mHD-ZIP family protein
Thhalv10000281mHD-ZIP family protein
Thhalv10026207mHD-ZIP family protein
Thhalv10006110mHD-ZIP family protein
Thhalv10025921mHD-ZIP family protein
Thhalv10008487mHD-ZIP family protein
Thhalv10022816mHD-ZIP family protein
Thhalv10022814mHD-ZIP family protein
Thhalv10025923mHD-ZIP family protein
Thhalv10001600mHD-ZIP family protein
Thhalv10005612mHD-ZIP family protein
Thhalv10000990mHD-ZIP family protein
Thhalv10001113mHD-ZIP family protein
Thhalv10006221mHD-ZIP family protein
Thhalv10014547mHD-ZIP family protein
Thhalv10015784mHD-ZIP family protein
Thhalv10008672mHD-ZIP family protein
Thhalv10019141mHD-ZIP family protein
Thhalv10017567mHD-ZIP family protein
Thhalv10014905mHD-ZIP family protein
Thhalv10006934mHD-ZIP family protein
Thhalv10024488mHD-ZIP family protein
Thhalv10028459mHD-ZIP family protein
Thhalv10028440mHD-ZIP family protein
Thhalv10024403mHD-ZIP family protein
Thhalv10024404mHD-ZIP family protein
Thhalv10024405mHD-ZIP family protein
Thhalv10016241mHD-ZIP family protein
Thhalv10001317mHD-ZIP family protein
Thhalv10005786mHD-ZIP family protein
Thhalv10006792mHD-ZIP family protein
Thhalv10017809mHD-ZIP family protein
Thhalv10011238mHD-ZIP family protein
Thhalv10015677mHD-ZIP family protein
Thhalv10018189mHD-ZIP family protein
Thhalv10012678mHD-ZIP family protein
Thhalv10006969mHD-ZIP family protein
Thhalv10018234mHD-ZIP family protein
Thhalv10026759mHD-ZIP family protein
Thhalv10000776mHD-ZIP family protein
Thhalv10024265mHD-ZIP family protein
Thhalv10012776mHD-ZIP family protein
Thhalv10021974mHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401