PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Eucalyptus camaldulensis
M-type_MADS Family
Species TF ID Description
EcC001560.40M-type_MADS family protein
EcC001609.10M-type_MADS family protein
EcC002759.10M-type_MADS family protein
EcC002764.10M-type_MADS family protein
EcC003821.10M-type_MADS family protein
EcC003968.10M-type_MADS family protein
EcC003968.30M-type_MADS family protein
EcC004055.10M-type_MADS family protein
EcC004476.30M-type_MADS family protein
EcC006978.40M-type_MADS family protein
EcC008336.10M-type_MADS family protein
EcC009087.10M-type_MADS family protein
EcC014594.10M-type_MADS family protein
EcC014797.10M-type_MADS family protein
EcC015427.10M-type_MADS family protein
EcC016096.10M-type_MADS family protein
EcC016630.20M-type_MADS family protein
EcC017267.10M-type_MADS family protein
EcC020519.30M-type_MADS family protein
EcC025915.30M-type_MADS family protein
EcC026037.10M-type_MADS family protein
EcC026522.10M-type_MADS family protein
EcC027683.20M-type_MADS family protein
EcC028693.10M-type_MADS family protein
EcC030345.10M-type_MADS family protein
EcC031866.10M-type_MADS family protein
EcC031977.60M-type_MADS family protein
EcC033331.10M-type_MADS family protein
EcC033331.20M-type_MADS family protein
EcC034554.10M-type_MADS family protein
EcC034842.100M-type_MADS family protein
EcC035750.10M-type_MADS family protein
EcC037206.30M-type_MADS family protein
EcC037314.20M-type_MADS family protein
EcC038575.40M-type_MADS family protein
EcC038726.30M-type_MADS family protein
EcC038726.70M-type_MADS family protein
EcC038920.10M-type_MADS family protein
EcC041379.60M-type_MADS family protein
EcC043112.10M-type_MADS family protein
EcC043112.30M-type_MADS family protein
EcC043112.50M-type_MADS family protein
EcC046324.10M-type_MADS family protein
EcC046825.20M-type_MADS family protein
EcC046989.20M-type_MADS family protein
EcC048399.10M-type_MADS family protein
EcC048689.30M-type_MADS family protein
EcC048689.70M-type_MADS family protein
EcC049317.10M-type_MADS family protein
EcC049992.10M-type_MADS family protein
EcC050126.10M-type_MADS family protein
EcC050250.10M-type_MADS family protein
EcC050287.40M-type_MADS family protein
EcC050734.20M-type_MADS family protein
EcC050789.10M-type_MADS family protein
EcC050841.10M-type_MADS family protein
EcC050841.20M-type_MADS family protein
EcC050990.40M-type_MADS family protein
EcC051147.50M-type_MADS family protein
EcC051844.20M-type_MADS family protein
EcC051844.30M-type_MADS family protein
EcC052470.10M-type_MADS family protein
EcC052542.10M-type_MADS family protein
EcC052717.20M-type_MADS family protein
EcC052944.10M-type_MADS family protein
EcC052959.20M-type_MADS family protein
EcC052993.20M-type_MADS family protein
EcC053060.20M-type_MADS family protein
EcC053489.50M-type_MADS family protein
EcC053493.10M-type_MADS family protein
EcC053585.20M-type_MADS family protein
EcC053646.20M-type_MADS family protein
EcC054128.40M-type_MADS family protein
EcC054589.30M-type_MADS family protein
EcC054671.10M-type_MADS family protein
EcC054671.20M-type_MADS family protein
EcC054947.80M-type_MADS family protein
EcC055061.30M-type_MADS family protein
EcC055194.110M-type_MADS family protein
EcC055194.80M-type_MADS family protein
EcC055207.100M-type_MADS family protein
EcC055207.130M-type_MADS family protein
EcC055207.80M-type_MADS family protein
EcC055224.140M-type_MADS family protein
EcC062590.10M-type_MADS family protein
EcS505675.10M-type_MADS family protein
EcS509121.10M-type_MADS family protein
EcS519827.10M-type_MADS family protein
EcS522822.10M-type_MADS family protein
EcS528244.10M-type_MADS family protein
EcS533381.10M-type_MADS family protein
EcS540542.10M-type_MADS family protein
EcS580600.10M-type_MADS family protein
EcS581303.10M-type_MADS family protein
EcS586720.10M-type_MADS family protein
EcS594681.10M-type_MADS family protein
EcS601285.10M-type_MADS family protein
EcS647077.10M-type_MADS family protein
EcS670027.10M-type_MADS family protein
EcS671351.10M-type_MADS family protein
EcS675818.10M-type_MADS family protein
EcS713436.10M-type_MADS family protein
EcS726083.10M-type_MADS family protein
EcS729356.10M-type_MADS family protein
EcS733179.10M-type_MADS family protein
EcS735233.10M-type_MADS family protein
EcS766893.10M-type_MADS family protein
EcS767755.10M-type_MADS family protein
EcS778359.10M-type_MADS family protein
EcS785390.10M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513