PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Dichanthelium oligosanthes
bHLH Family
Species TF ID Description
Do000066.1bHLH family protein
Do000214.1bHLH family protein
Do000328.1bHLH family protein
Do000558.1bHLH family protein
Do000759.1bHLH family protein
Do000953.1bHLH family protein
Do001097.1bHLH family protein
Do001260.1bHLH family protein
Do001354.1bHLH family protein
Do001525.1bHLH family protein
Do001632.1bHLH family protein
Do001643.1bHLH family protein
Do002149.1bHLH family protein
Do002349.1bHLH family protein
Do002406.1bHLH family protein
Do002551.1bHLH family protein
Do002704.1bHLH family protein
Do002738.1bHLH family protein
Do003007.1bHLH family protein
Do003038.1bHLH family protein
Do003489.1bHLH family protein
Do003563.1bHLH family protein
Do003634.1bHLH family protein
Do003780.1bHLH family protein
Do003874.1bHLH family protein
Do004059.1bHLH family protein
Do004146.1bHLH family protein
Do004562.1bHLH family protein
Do004661.1bHLH family protein
Do004691.1bHLH family protein
Do004892.1bHLH family protein
Do005045.1bHLH family protein
Do005067.1bHLH family protein
Do005222.1bHLH family protein
Do005455.1bHLH family protein
Do005620.1bHLH family protein
Do005686.1bHLH family protein
Do005732.1bHLH family protein
Do005733.1bHLH family protein
Do005779.1bHLH family protein
Do006497.1bHLH family protein
Do006568.1bHLH family protein
Do006750.1bHLH family protein
Do006942.1bHLH family protein
Do006971.1bHLH family protein
Do007212.1bHLH family protein
Do007302.1bHLH family protein
Do007568.1bHLH family protein
Do007623.1bHLH family protein
Do007708.1bHLH family protein
Do007746.1bHLH family protein
Do008198.1bHLH family protein
Do008238.1bHLH family protein
Do008390.1bHLH family protein
Do008572.1bHLH family protein
Do008895.1bHLH family protein
Do009523.1bHLH family protein
Do009524.1bHLH family protein
Do009553.1bHLH family protein
Do009574.1bHLH family protein
Do009837.1bHLH family protein
Do010007.1bHLH family protein
Do010032.1bHLH family protein
Do010392.1bHLH family protein
Do010611.1bHLH family protein
Do011089.1bHLH family protein
Do011267.1bHLH family protein
Do011313.1bHLH family protein
Do011459.1bHLH family protein
Do011481.1bHLH family protein
Do011577.1bHLH family protein
Do012094.1bHLH family protein
Do012245.1bHLH family protein
Do012533.1bHLH family protein
Do012550.1bHLH family protein
Do012552.1bHLH family protein
Do012986.1bHLH family protein
Do013479.1bHLH family protein
Do013571.1bHLH family protein
Do013649.1bHLH family protein
Do013698.1bHLH family protein
Do014049.1bHLH family protein
Do014153.1bHLH family protein
Do014239.1bHLH family protein
Do015085.1bHLH family protein
Do015133.1bHLH family protein
Do015336.1bHLH family protein
Do015345.1bHLH family protein
Do015647.1bHLH family protein
Do015976.1bHLH family protein
Do015997.1bHLH family protein
Do016425.1bHLH family protein
Do016454.1bHLH family protein
Do016572.1bHLH family protein
Do017230.1bHLH family protein
Do017415.1bHLH family protein
Do017490.1bHLH family protein
Do018030.1bHLH family protein
Do018050.1bHLH family protein
Do018333.1bHLH family protein
Do018346.1bHLH family protein
Do019274.1bHLH family protein
Do019288.1bHLH family protein
Do019639.1bHLH family protein
Do019656.1bHLH family protein
Do019699.1bHLH family protein
Do019788.1bHLH family protein
Do020041.1bHLH family protein
Do020227.1bHLH family protein
Do020341.1bHLH family protein
Do020469.1bHLH family protein
Do020719.1bHLH family protein
Do020867.1bHLH family protein
Do020905.1bHLH family protein
Do021043.1bHLH family protein
Do021087.1bHLH family protein
Do021282.1bHLH family protein
Do021387.1bHLH family protein
Do021429.1bHLH family protein
Do022129.1bHLH family protein
Do022184.1bHLH family protein
Do022252.1bHLH family protein
Do022572.1bHLH family protein
Do022582.1bHLH family protein
Do022902.1bHLH family protein
Do023022.1bHLH family protein
Do023024.1bHLH family protein
Do023125.1bHLH family protein
Do023267.1bHLH family protein
Do023424.1bHLH family protein
Do023576.1bHLH family protein
Do024215.1bHLH family protein
Do024644.1bHLH family protein
Do024826.1bHLH family protein
Do024887.1bHLH family protein
Do025022.1bHLH family protein
Do025275.1bHLH family protein
Do025298.1bHLH family protein
Do025459.1bHLH family protein
Do025519.1bHLH family protein
Do025670.1bHLH family protein
Do026022.1bHLH family protein
Do026995.1bHLH family protein
Do027166.1bHLH family protein
Do027554.1bHLH family protein
Do027698.1bHLH family protein
Do027932.1bHLH family protein
Do028053.1bHLH family protein
Do028210.1bHLH family protein
Do028568.1bHLH family protein
Do028580.1bHLH family protein
Do028988.1bHLH family protein
Do029712.1bHLH family protein
Do029779.1bHLH family protein
Do029831.1bHLH family protein
Do029846.1bHLH family protein
Do030148.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250