PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Dichanthelium oligosanthes
HD-ZIP Family
Species TF ID Description
Do020747.1HD-ZIP family protein
Do011020.1HD-ZIP family protein
Do006082.1HD-ZIP family protein
Do013843.1HD-ZIP family protein
Do009454.1HD-ZIP family protein
Do012456.1HD-ZIP family protein
Do021580.1HD-ZIP family protein
Do010111.1HD-ZIP family protein
Do020070.1HD-ZIP family protein
Do026738.1HD-ZIP family protein
Do014702.1HD-ZIP family protein
Do000758.1HD-ZIP family protein
Do003629.1HD-ZIP family protein
Do010618.1HD-ZIP family protein
Do013308.1HD-ZIP family protein
Do007543.1HD-ZIP family protein
Do016360.1HD-ZIP family protein
Do006755.1HD-ZIP family protein
Do011892.1HD-ZIP family protein
Do018265.1HD-ZIP family protein
Do024203.1HD-ZIP family protein
Do026348.1HD-ZIP family protein
Do011846.1HD-ZIP family protein
Do006040.1HD-ZIP family protein
Do014741.1HD-ZIP family protein
Do002375.1HD-ZIP family protein
Do016693.1HD-ZIP family protein
Do002533.1HD-ZIP family protein
Do018432.1HD-ZIP family protein
Do013221.1HD-ZIP family protein
Do021311.1HD-ZIP family protein
Do027262.1HD-ZIP family protein
Do028825.1HD-ZIP family protein
Do020438.1HD-ZIP family protein
Do006873.1HD-ZIP family protein
Do006783.1HD-ZIP family protein
Do011906.1HD-ZIP family protein
Do000506.1HD-ZIP family protein
Do018128.1HD-ZIP family protein
Do004303.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401