PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Dorcoceras hygrometricum
bHLH Family
Species TF ID Description
KZV14558.1bHLH family protein
KZV15099.1bHLH family protein
KZV15104.1bHLH family protein
KZV15134.1bHLH family protein
KZV15421.1bHLH family protein
KZV15660.1bHLH family protein
KZV16000.1bHLH family protein
KZV16079.1bHLH family protein
KZV16460.1bHLH family protein
KZV16616.1bHLH family protein
KZV16912.1bHLH family protein
KZV18648.1bHLH family protein
KZV18759.1bHLH family protein
KZV19026.1bHLH family protein
KZV19244.1bHLH family protein
KZV19507.1bHLH family protein
KZV21183.1bHLH family protein
KZV21519.1bHLH family protein
KZV21610.1bHLH family protein
KZV21671.1bHLH family protein
KZV21767.1bHLH family protein
KZV21906.1bHLH family protein
KZV22475.1bHLH family protein
KZV23128.1bHLH family protein
KZV23785.1bHLH family protein
KZV24220.1bHLH family protein
KZV24647.1bHLH family protein
KZV24654.1bHLH family protein
KZV24722.1bHLH family protein
KZV24798.1bHLH family protein
KZV25351.1bHLH family protein
KZV25396.1bHLH family protein
KZV25723.1bHLH family protein
KZV25822.1bHLH family protein
KZV26208.1bHLH family protein
KZV26625.1bHLH family protein
KZV27348.1bHLH family protein
KZV27521.1bHLH family protein
KZV27621.1bHLH family protein
KZV28501.1bHLH family protein
KZV29365.1bHLH family protein
KZV29487.1bHLH family protein
KZV30113.1bHLH family protein
KZV30114.1bHLH family protein
KZV30908.1bHLH family protein
KZV31416.1bHLH family protein
KZV31538.1bHLH family protein
KZV31590.1bHLH family protein
KZV31601.1bHLH family protein
KZV32410.1bHLH family protein
KZV32837.1bHLH family protein
KZV32987.1bHLH family protein
KZV33201.1bHLH family protein
KZV34702.1bHLH family protein
KZV34856.1bHLH family protein
KZV36116.1bHLH family protein
KZV36445.1bHLH family protein
KZV37271.1bHLH family protein
KZV38021.1bHLH family protein
KZV38332.1bHLH family protein
KZV39578.1bHLH family protein
KZV40291.1bHLH family protein
KZV40881.1bHLH family protein
KZV42255.1bHLH family protein
KZV42654.1bHLH family protein
KZV43839.1bHLH family protein
KZV44365.1bHLH family protein
KZV44782.1bHLH family protein
KZV45166.1bHLH family protein
KZV45988.1bHLH family protein
KZV46214.1bHLH family protein
KZV46864.1bHLH family protein
KZV47133.1bHLH family protein
KZV47480.1bHLH family protein
KZV47605.1bHLH family protein
KZV48208.1bHLH family protein
KZV48393.1bHLH family protein
KZV48733.1bHLH family protein
KZV49652.1bHLH family protein
KZV49697.1bHLH family protein
KZV50275.1bHLH family protein
KZV50468.1bHLH family protein
KZV50554.1bHLH family protein
KZV50821.1bHLH family protein
KZV50882.1bHLH family protein
KZV51097.1bHLH family protein
KZV51892.1bHLH family protein
KZV52246.1bHLH family protein
KZV52714.1bHLH family protein
KZV52796.1bHLH family protein
KZV53252.1bHLH family protein
KZV53765.1bHLH family protein
KZV54478.1bHLH family protein
KZV54504.1bHLH family protein
KZV54517.1bHLH family protein
KZV54540.1bHLH family protein
KZV54566.1bHLH family protein
KZV54575.1bHLH family protein
KZV54605.1bHLH family protein
KZV55191.1bHLH family protein
KZV55966.1bHLH family protein
KZV56030.1bHLH family protein
KZV56220.1bHLH family protein
KZV56460.1bHLH family protein
KZV56940.1bHLH family protein
KZV57040.1bHLH family protein
KZV57182.1bHLH family protein
KZV57541.1bHLH family protein
KZV58189.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250