PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Dorcoceras hygrometricum
HD-ZIP Family
Species TF ID Description
KZV55882.1HD-ZIP family protein
KZV49469.1HD-ZIP family protein
KZV30100.1HD-ZIP family protein
KZV36410.1HD-ZIP family protein
KZV58763.1HD-ZIP family protein
KZV53764.1HD-ZIP family protein
KZV43501.1HD-ZIP family protein
KZV45078.1HD-ZIP family protein
KZV53315.1HD-ZIP family protein
KZV32251.1HD-ZIP family protein
KZV58781.1HD-ZIP family protein
KZV23346.1HD-ZIP family protein
KZV57029.1HD-ZIP family protein
KZV14284.1HD-ZIP family protein
KZV47512.1HD-ZIP family protein
KZV38526.1HD-ZIP family protein
KZV21686.1HD-ZIP family protein
KZV41670.1HD-ZIP family protein
KZV38237.1HD-ZIP family protein
KZT76802.1HD-ZIP family protein
KZV29917.1HD-ZIP family protein
KZV14716.1HD-ZIP family protein
KZV19009.1HD-ZIP family protein
KZV50878.1HD-ZIP family protein
KZV45956.1HD-ZIP family protein
KZV36397.1HD-ZIP family protein
KZV51113.1HD-ZIP family protein
KZV13941.1HD-ZIP family protein
KZV14591.1HD-ZIP family protein
KZV33950.1HD-ZIP family protein
KZV37159.1HD-ZIP family protein
KZV51409.1HD-ZIP family protein
KZV55179.1HD-ZIP family protein
KZV41623.1HD-ZIP family protein
KZV57631.1HD-ZIP family protein
KZV56104.1HD-ZIP family protein
KZV26725.1HD-ZIP family protein
KZV32806.1HD-ZIP family protein
KZV58832.1HD-ZIP family protein
KZV14686.1HD-ZIP family protein
KZV49964.1HD-ZIP family protein
KZV34775.1HD-ZIP family protein
KZV41040.1HD-ZIP family protein
KZV18205.1HD-ZIP family protein
KZV14626.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401