PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Dianthus caryophyllus
HD-ZIP Family
Species TF ID Description
Dca2137.1HD-ZIP family protein
Dca55125.1HD-ZIP family protein
Dca6482.1HD-ZIP family protein
Dca51071.1HD-ZIP family protein
Dca11196.1HD-ZIP family protein
Dca31471.1HD-ZIP family protein
Dca22615.1HD-ZIP family protein
Dca26661.1HD-ZIP family protein
Dca53982.1HD-ZIP family protein
Dca5222.1HD-ZIP family protein
Dca44732.1HD-ZIP family protein
Dca53221.1HD-ZIP family protein
Dca7449.1HD-ZIP family protein
Dca15454.1HD-ZIP family protein
Dca60817.1HD-ZIP family protein
Dca41434.1HD-ZIP family protein
Dca62226.1HD-ZIP family protein
Dca37214.1HD-ZIP family protein
Dca61168.1HD-ZIP family protein
Dca36793.1HD-ZIP family protein
Dca54042.1HD-ZIP family protein
Dca19084.1HD-ZIP family protein
Dca20472.1HD-ZIP family protein
Dca52360.1HD-ZIP family protein
Dca18228.1HD-ZIP family protein
Dca37221.1HD-ZIP family protein
Dca4974.1HD-ZIP family protein
Dca36866.1HD-ZIP family protein
Dca8766.1HD-ZIP family protein
Dca42608.1HD-ZIP family protein
Dca19176.1HD-ZIP family protein
Dca26965.1HD-ZIP family protein
Dca53252.1HD-ZIP family protein
Dca28507.1HD-ZIP family protein
Dca14666.1HD-ZIP family protein
Dca59874.1HD-ZIP family protein
Dca38856.1HD-ZIP family protein
Dca48543.1HD-ZIP family protein
Dca55786.1HD-ZIP family protein
Dca54927.1HD-ZIP family protein
Dca57217.1HD-ZIP family protein
Dca19784.1HD-ZIP family protein
Dca61883.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401