PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Cannabis sativa
WRKY Family
Species TF ID Description
PK00408.1WRKY family protein
PK00408.2WRKY family protein
PK03324.1WRKY family protein
PK04475.1WRKY family protein
PK05432.1WRKY family protein
PK06890.1WRKY family protein
PK07646.1WRKY family protein
PK07706.2WRKY family protein
PK08266.1WRKY family protein
PK08451.1WRKY family protein
PK08776.1WRKY family protein
PK09209.1WRKY family protein
PK09975.1WRKY family protein
PK10616.1WRKY family protein
PK10734.1WRKY family protein
PK10836.7WRKY family protein
PK11028.1WRKY family protein
PK11867.1WRKY family protein
PK11867.2WRKY family protein
PK12811.1WRKY family protein
PK12935.1WRKY family protein
PK14075.1WRKY family protein
PK14983.1WRKY family protein
PK15688.1WRKY family protein
PK16035.1WRKY family protein
PK16035.2WRKY family protein
PK16045.1WRKY family protein
PK16897.4WRKY family protein
PK17638.1WRKY family protein
PK19604.1WRKY family protein
PK20163.1WRKY family protein
PK20695.1WRKY family protein
PK20698.1WRKY family protein
PK20894.1WRKY family protein
PK21041.1WRKY family protein
PK21300.1WRKY family protein
PK21378.1WRKY family protein
PK21971.1WRKY family protein
PK23889.1WRKY family protein
PK24436.1WRKY family protein
PK25870.1WRKY family protein
PK25933.1WRKY family protein
PK26499.1WRKY family protein
PK26982.1WRKY family protein
PK27953.1WRKY family protein
PK28616.1WRKY family protein
PK29640.1WRKY family protein
PK29664.1WRKY family protein
PK29806.1WRKY family protein
WRKY Family Introduction

WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.

The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).

Rushton PJ, Somssich IE, Ringler P, Shen QJ.
WRKY transcription factors.
Trends Plant Sci, 2010. 15(5): p. 247-58.
PMID: 20304701