PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Cannabis sativa
HD-ZIP Family
Species TF ID Description
PK05853.1HD-ZIP family protein
PK26879.1HD-ZIP family protein
PK20392.1HD-ZIP family protein
PK21887.1HD-ZIP family protein
PK26879.2HD-ZIP family protein
PK05260.1HD-ZIP family protein
PK18992.1HD-ZIP family protein
PK12774.2HD-ZIP family protein
PK07873.1HD-ZIP family protein
PK17424.1HD-ZIP family protein
PK17334.1HD-ZIP family protein
PK03912.2HD-ZIP family protein
PK14809.1HD-ZIP family protein
PK03912.1HD-ZIP family protein
PK19571.1HD-ZIP family protein
PK03054.1HD-ZIP family protein
PK15571.1HD-ZIP family protein
PK15535.1HD-ZIP family protein
PK12360.1HD-ZIP family protein
PK15571.2HD-ZIP family protein
PK06948.1HD-ZIP family protein
PK16243.1HD-ZIP family protein
PK19449.1HD-ZIP family protein
PK08504.1HD-ZIP family protein
PK00670.1HD-ZIP family protein
PK24181.1HD-ZIP family protein
PK01613.1HD-ZIP family protein
PK07568.1HD-ZIP family protein
PK07866.1HD-ZIP family protein
PK08284.1HD-ZIP family protein
PK14673.1HD-ZIP family protein
PK00670.3HD-ZIP family protein
PK00670.2HD-ZIP family protein
PK00670.4HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401