PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Cannabis sativa
E2F/DP Family
Species TF ID Description
PK00080.1E2F/DP family protein
PK00080.2E2F/DP family protein
PK04229.1E2F/DP family protein
PK04229.2E2F/DP family protein
PK09429.1E2F/DP family protein
PK09434.1E2F/DP family protein
PK10877.1E2F/DP family protein
PK10877.2E2F/DP family protein
PK10965.1E2F/DP family protein
PK11630.1E2F/DP family protein
PK18387.1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710