PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Capsella rubella
HD-ZIP Family
Species TF ID Description
Carubv10015805mHD-ZIP family protein
Carubv10020715mHD-ZIP family protein
Carubv10001498mHD-ZIP family protein
Carubv10001356mHD-ZIP family protein
Carubv10023682mHD-ZIP family protein
Carubv10005341mHD-ZIP family protein
Carubv10026808mHD-ZIP family protein
Carubv10023896mHD-ZIP family protein
Carubv10006436mHD-ZIP family protein
Carubv10005427mHD-ZIP family protein
Carubv10005275mHD-ZIP family protein
Carubv10014214mHD-ZIP family protein
Carubv10010076mHD-ZIP family protein
Carubv10005434mHD-ZIP family protein
Carubv10023690mHD-ZIP family protein
Carubv10023652mHD-ZIP family protein
Carubv10014605mHD-ZIP family protein
Carubv10014603mHD-ZIP family protein
Carubv10017588mHD-ZIP family protein
Carubv10026931mHD-ZIP family protein
Carubv10027040mHD-ZIP family protein
Carubv10017961mHD-ZIP family protein
Carubv10017952mHD-ZIP family protein
Carubv10002440mHD-ZIP family protein
Carubv10011442mHD-ZIP family protein
Carubv10024148mHD-ZIP family protein
Carubv10003464mHD-ZIP family protein
Carubv10021036mHD-ZIP family protein
Carubv10002831mHD-ZIP family protein
Carubv10027280mHD-ZIP family protein
Carubv10019989mHD-ZIP family protein
Carubv10008621mHD-ZIP family protein
Carubv10000303mHD-ZIP family protein
Carubv10000300mHD-ZIP family protein
Carubv10000257mHD-ZIP family protein
Carubv10006895mHD-ZIP family protein
Carubv10004127mHD-ZIP family protein
Carubv10022629mHD-ZIP family protein
Carubv10016704mHD-ZIP family protein
Carubv10022677mHD-ZIP family protein
Carubv10008304mHD-ZIP family protein
Carubv10012162mHD-ZIP family protein
Carubv10022676mHD-ZIP family protein
Carubv10021491mHD-ZIP family protein
Carubv10025876mHD-ZIP family protein
Carubv10008485mHD-ZIP family protein
Carubv10028346mHD-ZIP family protein
Carubv10028088mHD-ZIP family protein
Carubv10007084mHD-ZIP family protein
Carubv10007218mHD-ZIP family protein
Carubv10015764mHD-ZIP family protein
Carubv10011882mHD-ZIP family protein
Carubv10002574mHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401