PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Catharanthus roseus
HD-ZIP Family
Species TF ID Description
cra_locus_1635_iso_2HD-ZIP family protein
cra_locus_1635_iso_1HD-ZIP family protein
cra_locus_22954_iso_1HD-ZIP family protein
cra_locus_507_iso_6HD-ZIP family protein
cra_locus_1635_iso_3HD-ZIP family protein
cra_locus_507_iso_2HD-ZIP family protein
cra_locus_507_iso_3HD-ZIP family protein
cra_locus_507_iso_4HD-ZIP family protein
cra_locus_507_iso_7HD-ZIP family protein
cra_locus_507_iso_8HD-ZIP family protein
cra_locus_1081_iso_2HD-ZIP family protein
cra_locus_1081_iso_4HD-ZIP family protein
cra_locus_11227_iso_2HD-ZIP family protein
cra_locus_11227_iso_4HD-ZIP family protein
cra_locus_11227_iso_5HD-ZIP family protein
cra_locus_11227_iso_3HD-ZIP family protein
cra_locus_1901_iso_3HD-ZIP family protein
cra_locus_1901_iso_1HD-ZIP family protein
cra_locus_1901_iso_5HD-ZIP family protein
cra_locus_68351_iso_1HD-ZIP family protein
cra_locus_16080_iso_2HD-ZIP family protein
cra_locus_7817_iso_2HD-ZIP family protein
cra_locus_76899_iso_1HD-ZIP family protein
cra_locus_6945_iso_4HD-ZIP family protein
cra_locus_6945_iso_3HD-ZIP family protein
cra_locus_6945_iso_1HD-ZIP family protein
cra_locus_6945_iso_2HD-ZIP family protein
cra_locus_6945_iso_7HD-ZIP family protein
cra_locus_3849_iso_3HD-ZIP family protein
cra_locus_3849_iso_1HD-ZIP family protein
cra_locus_3849_iso_6HD-ZIP family protein
cra_locus_3849_iso_4HD-ZIP family protein
cra_locus_3991_iso_1HD-ZIP family protein
cra_locus_3991_iso_2HD-ZIP family protein
cra_locus_3991_iso_5HD-ZIP family protein
cra_locus_64452_iso_1HD-ZIP family protein
cra_locus_30366_iso_1HD-ZIP family protein
cra_locus_4276_iso_2HD-ZIP family protein
cra_locus_12433_iso_1HD-ZIP family protein
cra_locus_3299_iso_1HD-ZIP family protein
cra_locus_3299_iso_2HD-ZIP family protein
cra_locus_16080_iso_1HD-ZIP family protein
cra_locus_8916_iso_1HD-ZIP family protein
cra_locus_8916_iso_2HD-ZIP family protein
cra_locus_23063_iso_1HD-ZIP family protein
cra_locus_30222_iso_2HD-ZIP family protein
cra_locus_507_iso_1HD-ZIP family protein
cra_locus_1081_iso_3HD-ZIP family protein
cra_locus_30222_iso_1HD-ZIP family protein
cra_locus_30222_iso_3HD-ZIP family protein
cra_locus_3991_iso_3HD-ZIP family protein
cra_locus_5262_iso_1HD-ZIP family protein
cra_locus_41952_iso_1HD-ZIP family protein
cra_locus_2496_iso_1HD-ZIP family protein
cra_locus_2496_iso_3HD-ZIP family protein
cra_locus_1920_iso_4HD-ZIP family protein
cra_locus_4916_iso_1HD-ZIP family protein
cra_locus_4916_iso_4HD-ZIP family protein
cra_locus_14361_iso_3HD-ZIP family protein
cra_locus_15637_iso_2HD-ZIP family protein
cra_locus_5090_iso_1HD-ZIP family protein
cra_locus_5090_iso_7HD-ZIP family protein
cra_locus_5090_iso_4HD-ZIP family protein
cra_locus_5090_iso_8HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401