PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Chlorella variabilis NC64A
bZIP Family
Species TF ID Description
estExt_fgenesh3_pg.C_50017bZIP family protein
estExt_fgenesh3_pg.C_50059bZIP family protein
fgenesh3_pg.C_scaffold_1000250bZIP family protein
fgenesh3_pg.C_scaffold_38000010bZIP family protein
IGS.gm_10_00281bZIP family protein
IGS.gm_1_00289bZIP family protein
IGS.gm_1_00371bZIP family protein
IGS.gm_20_00224bZIP family protein
IGS.gm_2_00406bZIP family protein
IGS.gm_25_00067bZIP family protein
IGS.gm_32_00006bZIP family protein
IGS.gm_6_00503bZIP family protein
IGS.gm_9_00103bZIP family protein
bZIP Family Introduction

The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.

Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Jakoby M, Weisshaar B, Droge-Laser W, Vicente-Carbajosa J, Tiedemann J, Kroj T, Parcy F
bZIP transcription factors in Arabidopsis.
Trends Plant Sci, 2002. 7(3): p. 106-11.
PMID: 11906833