PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Cucumis melo
bHLH Family
Species TF ID Description
MELO3C001968P1bHLH family protein
MELO3C002012P1bHLH family protein
MELO3C002012P2bHLH family protein
MELO3C002057P1bHLH family protein
MELO3C002057P2bHLH family protein
MELO3C002057P3bHLH family protein
MELO3C002089P1bHLH family protein
MELO3C002089P2bHLH family protein
MELO3C002197P1bHLH family protein
MELO3C002383P1bHLH family protein
MELO3C002385P1bHLH family protein
MELO3C002385P2bHLH family protein
MELO3C002507P1bHLH family protein
MELO3C002522P1bHLH family protein
MELO3C002608P1bHLH family protein
MELO3C002608P2bHLH family protein
MELO3C002608P3bHLH family protein
MELO3C002608P4bHLH family protein
MELO3C002644P1bHLH family protein
MELO3C002870P1bHLH family protein
MELO3C003412P1bHLH family protein
MELO3C003421P1bHLH family protein
MELO3C003492P1bHLH family protein
MELO3C003797P2bHLH family protein
MELO3C003797P3bHLH family protein
MELO3C003968P1bHLH family protein
MELO3C003968P2bHLH family protein
MELO3C003968P3bHLH family protein
MELO3C003968P4bHLH family protein
MELO3C003968P5bHLH family protein
MELO3C004148P1bHLH family protein
MELO3C004148P2bHLH family protein
MELO3C004287P1bHLH family protein
MELO3C004429P1bHLH family protein
MELO3C004627P1bHLH family protein
MELO3C005178P1bHLH family protein
MELO3C005178P2bHLH family protein
MELO3C005178P3bHLH family protein
MELO3C005610P1bHLH family protein
MELO3C005610P2bHLH family protein
MELO3C005928P1bHLH family protein
MELO3C005928P2bHLH family protein
MELO3C005928P3bHLH family protein
MELO3C005928P4bHLH family protein
MELO3C006016P1bHLH family protein
MELO3C006315P1bHLH family protein
MELO3C006435P1bHLH family protein
MELO3C006563P1bHLH family protein
MELO3C006612P1bHLH family protein
MELO3C006789P1bHLH family protein
MELO3C006789P2bHLH family protein
MELO3C006854P1bHLH family protein
MELO3C007341P1bHLH family protein
MELO3C007341P2bHLH family protein
MELO3C007570P1bHLH family protein
MELO3C007678P1bHLH family protein
MELO3C007679P1bHLH family protein
MELO3C007680P1bHLH family protein
MELO3C007694P1bHLH family protein
MELO3C007694P2bHLH family protein
MELO3C007720P1bHLH family protein
MELO3C007905P1bHLH family protein
MELO3C008047P1bHLH family protein
MELO3C008307P1bHLH family protein
MELO3C008668P1bHLH family protein
MELO3C009231P1bHLH family protein
MELO3C009231P3bHLH family protein
MELO3C009231P4bHLH family protein
MELO3C009651P1bHLH family protein
MELO3C009653P1bHLH family protein
MELO3C009653P2bHLH family protein
MELO3C010237P1bHLH family protein
MELO3C010783P1bHLH family protein
MELO3C010783P2bHLH family protein
MELO3C010811P1bHLH family protein
MELO3C010843P1bHLH family protein
MELO3C010848P1bHLH family protein
MELO3C011052P1bHLH family protein
MELO3C011052P2bHLH family protein
MELO3C011094P1bHLH family protein
MELO3C011110P1bHLH family protein
MELO3C011399P1bHLH family protein
MELO3C011994P1bHLH family protein
MELO3C012081P1bHLH family protein
MELO3C012177P1bHLH family protein
MELO3C012213P1bHLH family protein
MELO3C012808P1bHLH family protein
MELO3C013023P1bHLH family protein
MELO3C013453P1bHLH family protein
MELO3C013627P1bHLH family protein
MELO3C013772P1bHLH family protein
MELO3C013782P1bHLH family protein
MELO3C013851P1bHLH family protein
MELO3C014406P1bHLH family protein
MELO3C014408P1bHLH family protein
MELO3C014408P2bHLH family protein
MELO3C014408P3bHLH family protein
MELO3C014408P4bHLH family protein
MELO3C014812P1bHLH family protein
MELO3C015207P1bHLH family protein
MELO3C015379P1bHLH family protein
MELO3C015379P2bHLH family protein
MELO3C015488P1bHLH family protein
MELO3C015748P1bHLH family protein
MELO3C015760P1bHLH family protein
MELO3C016763P1bHLH family protein
MELO3C016810P1bHLH family protein
MELO3C016841P1bHLH family protein
MELO3C017140P1bHLH family protein
MELO3C017164P1bHLH family protein
MELO3C017166P2bHLH family protein
MELO3C017202P1bHLH family protein
MELO3C017257P1bHLH family protein
MELO3C017314P1bHLH family protein
MELO3C017314P2bHLH family protein
MELO3C017424P1bHLH family protein
MELO3C017669P1bHLH family protein
MELO3C017761P1bHLH family protein
MELO3C017761P2bHLH family protein
MELO3C017996P1bHLH family protein
MELO3C018123P1bHLH family protein
MELO3C018125P1bHLH family protein
MELO3C018451P1bHLH family protein
MELO3C018496P1bHLH family protein
MELO3C018516P1bHLH family protein
MELO3C018555P1bHLH family protein
MELO3C018728P1bHLH family protein
MELO3C018792P1bHLH family protein
MELO3C018898P1bHLH family protein
MELO3C018898P2bHLH family protein
MELO3C018898P3bHLH family protein
MELO3C019063P1bHLH family protein
MELO3C019065P1bHLH family protein
MELO3C019065P2bHLH family protein
MELO3C019226P1bHLH family protein
MELO3C019736P1bHLH family protein
MELO3C019758P1bHLH family protein
MELO3C020189P1bHLH family protein
MELO3C020370P1bHLH family protein
MELO3C020417P1bHLH family protein
MELO3C020437P1bHLH family protein
MELO3C020781P1bHLH family protein
MELO3C020782P2bHLH family protein
MELO3C020892P1bHLH family protein
MELO3C021101P1bHLH family protein
MELO3C021212P1bHLH family protein
MELO3C021212P2bHLH family protein
MELO3C021653P1bHLH family protein
MELO3C021981P1bHLH family protein
MELO3C022222P1bHLH family protein
MELO3C022222P2bHLH family protein
MELO3C022233P1bHLH family protein
MELO3C022250P1bHLH family protein
MELO3C022574P1bHLH family protein
MELO3C022846P1bHLH family protein
MELO3C023299P1bHLH family protein
MELO3C023532P2bHLH family protein
MELO3C023532P4bHLH family protein
MELO3C023532P5bHLH family protein
MELO3C023532P6bHLH family protein
MELO3C024041P1bHLH family protein
MELO3C024041P2bHLH family protein
MELO3C024155P1bHLH family protein
MELO3C024411P1bHLH family protein
MELO3C024696P1bHLH family protein
MELO3C026008P1bHLH family protein
MELO3C026173P1bHLH family protein
MELO3C026410P1bHLH family protein
MELO3C026410P2bHLH family protein
MELO3C026410P3bHLH family protein
MELO3C026410P4bHLH family protein
MELO3C026503P1bHLH family protein
MELO3C026599P1bHLH family protein
MELO3C026778P1bHLH family protein
MELO3C026933P1bHLH family protein
MELO3C026952P1bHLH family protein
MELO3C027216P1bHLH family protein
MELO3C027290P1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250