PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Cucumis melo
HD-ZIP Family
Species TF ID Description
MELO3C009948P1HD-ZIP family protein
MELO3C009948P2HD-ZIP family protein
MELO3C012079P1HD-ZIP family protein
MELO3C002209P2HD-ZIP family protein
MELO3C002209P1HD-ZIP family protein
MELO3C013923P1HD-ZIP family protein
MELO3C021534P1HD-ZIP family protein
MELO3C021534P2HD-ZIP family protein
MELO3C023514P1HD-ZIP family protein
MELO3C005978P1HD-ZIP family protein
MELO3C021978P1HD-ZIP family protein
MELO3C007736P2HD-ZIP family protein
MELO3C007736P1HD-ZIP family protein
MELO3C007666P1HD-ZIP family protein
MELO3C009614P1HD-ZIP family protein
MELO3C014944P1HD-ZIP family protein
MELO3C005992P1HD-ZIP family protein
MELO3C009420P1HD-ZIP family protein
MELO3C003554P1HD-ZIP family protein
MELO3C024507P1HD-ZIP family protein
MELO3C017407P1HD-ZIP family protein
MELO3C012064P1HD-ZIP family protein
MELO3C007809P1HD-ZIP family protein
MELO3C017549P1HD-ZIP family protein
MELO3C005327P1HD-ZIP family protein
MELO3C023937P1HD-ZIP family protein
MELO3C016081P1HD-ZIP family protein
MELO3C019250P1HD-ZIP family protein
MELO3C018809P1HD-ZIP family protein
MELO3C022532P1HD-ZIP family protein
MELO3C024256P1HD-ZIP family protein
MELO3C002477P1HD-ZIP family protein
MELO3C007377P1HD-ZIP family protein
MELO3C024446P2HD-ZIP family protein
MELO3C024446P1HD-ZIP family protein
MELO3C001940P1HD-ZIP family protein
MELO3C003468P1HD-ZIP family protein
MELO3C006887P1HD-ZIP family protein
MELO3C002807P1HD-ZIP family protein
MELO3C007078P2HD-ZIP family protein
MELO3C007078P1HD-ZIP family protein
MELO3C003433P1HD-ZIP family protein
MELO3C025774P1HD-ZIP family protein
MELO3C025774P2HD-ZIP family protein
MELO3C025774P4HD-ZIP family protein
MELO3C025774P3HD-ZIP family protein
MELO3C020321P1HD-ZIP family protein
MELO3C012973P1HD-ZIP family protein
MELO3C004887P1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401