PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Citrus clementina
Species TF ID Description
Ciclev10001730mMIKC_MADS family protein
Ciclev10002410mMIKC_MADS family protein
Ciclev10002422mMIKC_MADS family protein
Ciclev10002471mMIKC_MADS family protein
Ciclev10003964mMIKC_MADS family protein
Ciclev10005698mMIKC_MADS family protein
Ciclev10009338mMIKC_MADS family protein
Ciclev10009472mMIKC_MADS family protein
Ciclev10009742mMIKC_MADS family protein
Ciclev10012593mMIKC_MADS family protein
Ciclev10012594mMIKC_MADS family protein
Ciclev10016394mMIKC_MADS family protein
Ciclev10016427mMIKC_MADS family protein
Ciclev10016430mMIKC_MADS family protein
Ciclev10016433mMIKC_MADS family protein
Ciclev10016819mMIKC_MADS family protein
Ciclev10021357mMIKC_MADS family protein
Ciclev10021367mMIKC_MADS family protein
Ciclev10021822mMIKC_MADS family protein
Ciclev10021911mMIKC_MADS family protein
Ciclev10022145mMIKC_MADS family protein
Ciclev10022147mMIKC_MADS family protein
Ciclev10022150mMIKC_MADS family protein
Ciclev10022568mMIKC_MADS family protein
Ciclev10023354mMIKC_MADS family protein
Ciclev10026433mMIKC_MADS family protein
Ciclev10026455mMIKC_MADS family protein
Ciclev10026457mMIKC_MADS family protein
Ciclev10026937mMIKC_MADS family protein
Ciclev10032489mMIKC_MADS family protein
Ciclev10032490mMIKC_MADS family protein
Ciclev10032507mMIKC_MADS family protein
Ciclev10032513mMIKC_MADS family protein
Ciclev10032519mMIKC_MADS family protein
Ciclev10032572mMIKC_MADS family protein
Ciclev10032578mMIKC_MADS family protein
Ciclev10032584mMIKC_MADS family protein
Ciclev10032589mMIKC_MADS family protein
Ciclev10032927mMIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513