PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Citrus clementina
HD-ZIP Family
Species TF ID Description
Ciclev10017539mHD-ZIP family protein
Ciclev10026013mHD-ZIP family protein
Ciclev10032275mHD-ZIP family protein
Ciclev10032279mHD-ZIP family protein
Ciclev10021374mHD-ZIP family protein
Ciclev10012352mHD-ZIP family protein
Ciclev10026197mHD-ZIP family protein
Ciclev10021535mHD-ZIP family protein
Ciclev10021501mHD-ZIP family protein
Ciclev10002232mHD-ZIP family protein
Ciclev10002235mHD-ZIP family protein
Ciclev10033853mHD-ZIP family protein
Ciclev10002182mHD-ZIP family protein
Ciclev10024310mHD-ZIP family protein
Ciclev10022365mHD-ZIP family protein
Ciclev10013382mHD-ZIP family protein
Ciclev10032229mHD-ZIP family protein
Ciclev10016477mHD-ZIP family protein
Ciclev10021877mHD-ZIP family protein
Ciclev10002208mHD-ZIP family protein
Ciclev10012525mHD-ZIP family protein
Ciclev10010326mHD-ZIP family protein
Ciclev10026414mHD-ZIP family protein
Ciclev10022253mHD-ZIP family protein
Ciclev10016895mHD-ZIP family protein
Ciclev10009522mHD-ZIP family protein
Ciclev10022336mHD-ZIP family protein
Ciclev10014424mHD-ZIP family protein
Ciclev10014425mHD-ZIP family protein
Ciclev10014370mHD-ZIP family protein
Ciclev10014372mHD-ZIP family protein
Ciclev10014373mHD-ZIP family protein
Ciclev10024950mHD-ZIP family protein
Ciclev10019064mHD-ZIP family protein
Ciclev10018857mHD-ZIP family protein
Ciclev10018855mHD-ZIP family protein
Ciclev10007435mHD-ZIP family protein
Ciclev10024891mHD-ZIP family protein
Ciclev10024892mHD-ZIP family protein
Ciclev10004453mHD-ZIP family protein
Ciclev10014266mHD-ZIP family protein
Ciclev10027790mHD-ZIP family protein
Ciclev10003996mHD-ZIP family protein
Ciclev10019153mHD-ZIP family protein
Ciclev10019691mHD-ZIP family protein
Ciclev10006467mHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401