PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Cajanus cajan
bHLH Family
Species TF ID Description
C.cajan_00271bHLH family protein
C.cajan_00341bHLH family protein
C.cajan_00400bHLH family protein
C.cajan_00414bHLH family protein
C.cajan_00681bHLH family protein
C.cajan_00797bHLH family protein
C.cajan_00960bHLH family protein
C.cajan_01079bHLH family protein
C.cajan_01166bHLH family protein
C.cajan_01740bHLH family protein
C.cajan_01947bHLH family protein
C.cajan_02477bHLH family protein
C.cajan_02676bHLH family protein
C.cajan_02909bHLH family protein
C.cajan_02946bHLH family protein
C.cajan_03364bHLH family protein
C.cajan_03586bHLH family protein
C.cajan_03714bHLH family protein
C.cajan_03771bHLH family protein
C.cajan_03803bHLH family protein
C.cajan_04591bHLH family protein
C.cajan_04962bHLH family protein
C.cajan_05093bHLH family protein
C.cajan_05308bHLH family protein
C.cajan_05513bHLH family protein
C.cajan_05545bHLH family protein
C.cajan_05797bHLH family protein
C.cajan_06845bHLH family protein
C.cajan_06954bHLH family protein
C.cajan_07682bHLH family protein
C.cajan_07782bHLH family protein
C.cajan_07783bHLH family protein
C.cajan_07813bHLH family protein
C.cajan_08009bHLH family protein
C.cajan_08127bHLH family protein
C.cajan_08656bHLH family protein
C.cajan_08718bHLH family protein
C.cajan_08881bHLH family protein
C.cajan_09326bHLH family protein
C.cajan_09364bHLH family protein
C.cajan_09391bHLH family protein
C.cajan_09523bHLH family protein
C.cajan_09677bHLH family protein
C.cajan_09728bHLH family protein
C.cajan_10210bHLH family protein
C.cajan_10645bHLH family protein
C.cajan_10677bHLH family protein
C.cajan_10906bHLH family protein
C.cajan_10908bHLH family protein
C.cajan_10967bHLH family protein
C.cajan_11546bHLH family protein
C.cajan_11771bHLH family protein
C.cajan_11858bHLH family protein
C.cajan_12242bHLH family protein
C.cajan_12303bHLH family protein
C.cajan_12324bHLH family protein
C.cajan_12749bHLH family protein
C.cajan_12756bHLH family protein
C.cajan_12990bHLH family protein
C.cajan_12992bHLH family protein
C.cajan_13347bHLH family protein
C.cajan_13469bHLH family protein
C.cajan_13634bHLH family protein
C.cajan_15614bHLH family protein
C.cajan_15679bHLH family protein
C.cajan_16321bHLH family protein
C.cajan_16964bHLH family protein
C.cajan_17609bHLH family protein
C.cajan_18198bHLH family protein
C.cajan_19569bHLH family protein
C.cajan_20106bHLH family protein
C.cajan_20209bHLH family protein
C.cajan_21224bHLH family protein
C.cajan_21593bHLH family protein
C.cajan_21862bHLH family protein
C.cajan_22707bHLH family protein
C.cajan_22803bHLH family protein
C.cajan_23511bHLH family protein
C.cajan_23795bHLH family protein
C.cajan_23878bHLH family protein
C.cajan_23954bHLH family protein
C.cajan_24391bHLH family protein
C.cajan_24660bHLH family protein
C.cajan_24678bHLH family protein
C.cajan_24883bHLH family protein
C.cajan_24887bHLH family protein
C.cajan_24893bHLH family protein
C.cajan_24916bHLH family protein
C.cajan_25264bHLH family protein
C.cajan_25563bHLH family protein
C.cajan_26410bHLH family protein
C.cajan_26806bHLH family protein
C.cajan_26851bHLH family protein
C.cajan_26864bHLH family protein
C.cajan_27872bHLH family protein
C.cajan_28045bHLH family protein
C.cajan_28049bHLH family protein
C.cajan_28060bHLH family protein
C.cajan_28075bHLH family protein
C.cajan_28596bHLH family protein
C.cajan_28936bHLH family protein
C.cajan_29000bHLH family protein
C.cajan_29039bHLH family protein
C.cajan_29333bHLH family protein
C.cajan_29734bHLH family protein
C.cajan_29823bHLH family protein
C.cajan_30140bHLH family protein
C.cajan_30334bHLH family protein
C.cajan_30396bHLH family protein
C.cajan_30524bHLH family protein
C.cajan_31085bHLH family protein
C.cajan_31086bHLH family protein
C.cajan_31209bHLH family protein
C.cajan_31215bHLH family protein
C.cajan_32230bHLH family protein
C.cajan_32511bHLH family protein
C.cajan_32656bHLH family protein
C.cajan_33214bHLH family protein
C.cajan_33239bHLH family protein
C.cajan_33272bHLH family protein
C.cajan_33777bHLH family protein
C.cajan_33809bHLH family protein
C.cajan_33810bHLH family protein
C.cajan_33811bHLH family protein
C.cajan_33812bHLH family protein
C.cajan_33813bHLH family protein
C.cajan_34129bHLH family protein
C.cajan_34204bHLH family protein
C.cajan_34237bHLH family protein
C.cajan_34336bHLH family protein
C.cajan_34338bHLH family protein
C.cajan_34834bHLH family protein
C.cajan_34930bHLH family protein
C.cajan_35118bHLH family protein
C.cajan_35885bHLH family protein
C.cajan_36068bHLH family protein
C.cajan_36273bHLH family protein
C.cajan_36335bHLH family protein
C.cajan_37582bHLH family protein
C.cajan_37599bHLH family protein
C.cajan_37639bHLH family protein
C.cajan_37803bHLH family protein
C.cajan_37903bHLH family protein
C.cajan_37996bHLH family protein
C.cajan_38105bHLH family protein
C.cajan_38744bHLH family protein
C.cajan_38793bHLH family protein
C.cajan_39418bHLH family protein
C.cajan_39862bHLH family protein
C.cajan_40006bHLH family protein
C.cajan_40336bHLH family protein
C.cajan_40694bHLH family protein
C.cajan_40927bHLH family protein
C.cajan_40972bHLH family protein
C.cajan_41132bHLH family protein
C.cajan_41140bHLH family protein
C.cajan_41142bHLH family protein
C.cajan_41697bHLH family protein
C.cajan_42628bHLH family protein
C.cajan_43151bHLH family protein
C.cajan_43189bHLH family protein
C.cajan_43441bHLH family protein
C.cajan_44432bHLH family protein
C.cajan_44447bHLH family protein
C.cajan_44487bHLH family protein
C.cajan_44519bHLH family protein
C.cajan_44547bHLH family protein
C.cajan_44593bHLH family protein
C.cajan_45328bHLH family protein
C.cajan_45330bHLH family protein
C.cajan_45406bHLH family protein
C.cajan_46335bHLH family protein
C.cajan_46853bHLH family protein
C.cajan_47684bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250