PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Camelina sativa
MIKC_MADS Family
Species TF ID Description
Csa01g001860.1MIKC_MADS family protein
Csa01g035280.1MIKC_MADS family protein
Csa02g016200.1MIKC_MADS family protein
Csa02g026980.1MIKC_MADS family protein
Csa02g044820.1MIKC_MADS family protein
Csa02g067860.1MIKC_MADS family protein
Csa02g068420.1MIKC_MADS family protein
Csa02g070220.1MIKC_MADS family protein
Csa02g073630.1MIKC_MADS family protein
Csa02g073640.1MIKC_MADS family protein
Csa02g073650.1MIKC_MADS family protein
Csa02g073660.1MIKC_MADS family protein
Csa03g029230.1MIKC_MADS family protein
Csa03g030490.1MIKC_MADS family protein
Csa04g009260.1MIKC_MADS family protein
Csa04g040410.1MIKC_MADS family protein
Csa04g040410.2MIKC_MADS family protein
Csa04g043810.1MIKC_MADS family protein
Csa04g046300.1MIKC_MADS family protein
Csa04g059420.1MIKC_MADS family protein
Csa04g063650.1MIKC_MADS family protein
Csa04g063660.1MIKC_MADS family protein
Csa05g003630.1MIKC_MADS family protein
Csa05g003640.1MIKC_MADS family protein
Csa05g008730.1MIKC_MADS family protein
Csa05g085820.1MIKC_MADS family protein
Csa05g085820.2MIKC_MADS family protein
Csa05g086270.1MIKC_MADS family protein
Csa05g086270.2MIKC_MADS family protein
Csa06g004600.1MIKC_MADS family protein
Csa06g012870.1MIKC_MADS family protein
Csa06g028820.1MIKC_MADS family protein
Csa06g032970.1MIKC_MADS family protein
Csa06g033110.1MIKC_MADS family protein
Csa06g036530.1MIKC_MADS family protein
Csa06g048980.1MIKC_MADS family protein
Csa06g052050.1MIKC_MADS family protein
Csa06g052060.1MIKC_MADS family protein
Csa07g035800.1MIKC_MADS family protein
Csa07g035800.2MIKC_MADS family protein
Csa07g036270.1MIKC_MADS family protein
Csa07g038550.1MIKC_MADS family protein
Csa07g050650.1MIKC_MADS family protein
Csa07g052630.1MIKC_MADS family protein
Csa07g052720.1MIKC_MADS family protein
Csa08g005750.1MIKC_MADS family protein
Csa08g007940.1MIKC_MADS family protein
Csa08g007940.2MIKC_MADS family protein
Csa08g014080.1MIKC_MADS family protein
Csa08g017610.1MIKC_MADS family protein
Csa08g038790.1MIKC_MADS family protein
Csa08g044170.1MIKC_MADS family protein
Csa08g054450.1MIKC_MADS family protein
Csa09g007030.1MIKC_MADS family protein
Csa09g025270.1MIKC_MADS family protein
Csa09g064040.1MIKC_MADS family protein
Csa09g064040.2MIKC_MADS family protein
Csa09g069840.1MIKC_MADS family protein
Csa09g071410.1MIKC_MADS family protein
Csa09g072930.1MIKC_MADS family protein
Csa09g083770.1MIKC_MADS family protein
Csa09g084730.1MIKC_MADS family protein
Csa09g086860.1MIKC_MADS family protein
Csa09g086950.1MIKC_MADS family protein
Csa10g003160.1MIKC_MADS family protein
Csa10g020140.1MIKC_MADS family protein
Csa11g019130.1MIKC_MADS family protein
Csa11g020190.1MIKC_MADS family protein
Csa11g083480.1MIKC_MADS family protein
Csa11g083490.1MIKC_MADS family protein
Csa11g094760.1MIKC_MADS family protein
Csa11g097260.1MIKC_MADS family protein
Csa11g099070.1MIKC_MADS family protein
Csa11g102240.1MIKC_MADS family protein
Csa11g102240.2MIKC_MADS family protein
Csa11g102250.1MIKC_MADS family protein
Csa11g102260.1MIKC_MADS family protein
Csa12g003420.1MIKC_MADS family protein
Csa12g027770.1MIKC_MADS family protein
Csa12g033740.1MIKC_MADS family protein
Csa13g016510.1MIKC_MADS family protein
Csa13g018600.1MIKC_MADS family protein
Csa13g023200.1MIKC_MADS family protein
Csa13g027840.1MIKC_MADS family protein
Csa13g044940.1MIKC_MADS family protein
Csa13g049070.1MIKC_MADS family protein
Csa14g032470.1MIKC_MADS family protein
Csa14g034830.1MIKC_MADS family protein
Csa15g001870.1MIKC_MADS family protein
Csa16g030440.1MIKC_MADS family protein
Csa16g030930.1MIKC_MADS family protein
Csa16g030930.2MIKC_MADS family protein
Csa16g030930.3MIKC_MADS family protein
Csa16g034280.1MIKC_MADS family protein
Csa16g041240.1MIKC_MADS family protein
Csa16g042220.1MIKC_MADS family protein
Csa16g044290.1MIKC_MADS family protein
Csa17g029050.1MIKC_MADS family protein
Csa17g034610.1MIKC_MADS family protein
Csa17g035980.1MIKC_MADS family protein
Csa17g048680.1MIKC_MADS family protein
Csa18g022730.1MIKC_MADS family protein
Csa18g022740.1MIKC_MADS family protein
Csa18g034280.1MIKC_MADS family protein
Csa18g034790.1MIKC_MADS family protein
Csa18g035660.1MIKC_MADS family protein
Csa18g038760.1MIKC_MADS family protein
Csa18g038770.1MIKC_MADS family protein
Csa19g002950.1MIKC_MADS family protein
Csa20g023310.1MIKC_MADS family protein
Csa20g032170.1MIKC_MADS family protein
Csa20g038200.1MIKC_MADS family protein
Csa20g038200.2MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513