PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Cicer arietinum
bHLH Family
Species TF ID Description
XP_004485645.1bHLH family protein
XP_004485676.1bHLH family protein
XP_004485677.1bHLH family protein
XP_004486145.1bHLH family protein
XP_004486628.1bHLH family protein
XP_004486629.1bHLH family protein
XP_004486757.1bHLH family protein
XP_004486946.1bHLH family protein
XP_004487166.1bHLH family protein
XP_004487228.1bHLH family protein
XP_004487368.1bHLH family protein
XP_004487384.1bHLH family protein
XP_004487563.1bHLH family protein
XP_004487616.1bHLH family protein
XP_004487634.1bHLH family protein
XP_004487635.1bHLH family protein
XP_004487636.1bHLH family protein
XP_004487637.1bHLH family protein
XP_004487998.1bHLH family protein
XP_004488061.1bHLH family protein
XP_004488862.1bHLH family protein
XP_004488863.1bHLH family protein
XP_004489383.1bHLH family protein
XP_004489760.1bHLH family protein
XP_004489860.1bHLH family protein
XP_004489951.1bHLH family protein
XP_004490021.1bHLH family protein
XP_004490261.1bHLH family protein
XP_004490274.2bHLH family protein
XP_004490291.1bHLH family protein
XP_004490292.1bHLH family protein
XP_004490333.1bHLH family protein
XP_004490443.1bHLH family protein
XP_004491783.1bHLH family protein
XP_004491945.1bHLH family protein
XP_004491946.1bHLH family protein
XP_004492265.1bHLH family protein
XP_004492885.1bHLH family protein
XP_004492886.1bHLH family protein
XP_004493068.1bHLH family protein
XP_004493069.1bHLH family protein
XP_004493384.1bHLH family protein
XP_004493429.1bHLH family protein
XP_004493546.1bHLH family protein
XP_004493549.1bHLH family protein
XP_004493550.1bHLH family protein
XP_004493736.1bHLH family protein
XP_004493737.1bHLH family protein
XP_004493757.1bHLH family protein
XP_004493767.1bHLH family protein
XP_004493863.1bHLH family protein
XP_004493864.1bHLH family protein
XP_004494480.1bHLH family protein
XP_004494635.1bHLH family protein
XP_004494832.1bHLH family protein
XP_004495025.1bHLH family protein
XP_004495148.1bHLH family protein
XP_004495294.1bHLH family protein
XP_004495746.1bHLH family protein
XP_004495811.1bHLH family protein
XP_004495812.1bHLH family protein
XP_004496205.1bHLH family protein
XP_004496220.1bHLH family protein
XP_004496221.1bHLH family protein
XP_004496639.1bHLH family protein
XP_004496640.1bHLH family protein
XP_004496878.1bHLH family protein
XP_004497179.1bHLH family protein
XP_004497269.1bHLH family protein
XP_004497415.1bHLH family protein
XP_004497838.1bHLH family protein
XP_004498014.1bHLH family protein
XP_004498015.1bHLH family protein
XP_004498438.1bHLH family protein
XP_004498946.1bHLH family protein
XP_004498947.1bHLH family protein
XP_004499006.1bHLH family protein
XP_004499048.1bHLH family protein
XP_004499049.1bHLH family protein
XP_004499430.1bHLH family protein
XP_004499538.1bHLH family protein
XP_004499539.1bHLH family protein
XP_004499540.1bHLH family protein
XP_004500503.1bHLH family protein
XP_004500808.1bHLH family protein
XP_004500989.1bHLH family protein
XP_004501060.1bHLH family protein
XP_004501478.1bHLH family protein
XP_004501682.1bHLH family protein
XP_004501739.1bHLH family protein
XP_004501748.1bHLH family protein
XP_004501802.2bHLH family protein
XP_004501808.1bHLH family protein
XP_004502611.1bHLH family protein
XP_004503713.1bHLH family protein
XP_004503788.1bHLH family protein
XP_004503789.1bHLH family protein
XP_004503790.1bHLH family protein
XP_004503791.1bHLH family protein
XP_004503793.1bHLH family protein
XP_004503794.1bHLH family protein
XP_004504117.1bHLH family protein
XP_004504639.1bHLH family protein
XP_004504883.2bHLH family protein
XP_004504967.1bHLH family protein
XP_004505138.1bHLH family protein
XP_004505158.1bHLH family protein
XP_004505159.1bHLH family protein
XP_004505161.1bHLH family protein
XP_004505238.1bHLH family protein
XP_004505414.1bHLH family protein
XP_004505433.1bHLH family protein
XP_004505503.1bHLH family protein
XP_004505689.1bHLH family protein
XP_004505690.1bHLH family protein
XP_004506077.1bHLH family protein
XP_004506301.1bHLH family protein
XP_004507453.1bHLH family protein
XP_004507723.1bHLH family protein
XP_004508610.1bHLH family protein
XP_004508645.1bHLH family protein
XP_004508802.1bHLH family protein
XP_004508803.1bHLH family protein
XP_004509135.1bHLH family protein
XP_004509726.1bHLH family protein
XP_004509733.1bHLH family protein
XP_004509761.1bHLH family protein
XP_004509763.1bHLH family protein
XP_004509816.1bHLH family protein
XP_004509817.1bHLH family protein
XP_004509918.1bHLH family protein
XP_004509985.1bHLH family protein
XP_004509986.1bHLH family protein
XP_004510231.1bHLH family protein
XP_004510332.2bHLH family protein
XP_004510627.1bHLH family protein
XP_004510665.1bHLH family protein
XP_004510971.1bHLH family protein
XP_004511222.1bHLH family protein
XP_004511446.1bHLH family protein
XP_004511793.1bHLH family protein
XP_004511794.1bHLH family protein
XP_004511795.1bHLH family protein
XP_004511915.1bHLH family protein
XP_004511923.1bHLH family protein
XP_004512525.1bHLH family protein
XP_004512545.1bHLH family protein
XP_004512905.1bHLH family protein
XP_004513200.1bHLH family protein
XP_004514235.1bHLH family protein
XP_004514916.2bHLH family protein
XP_004515539.1bHLH family protein
XP_004515594.1bHLH family protein
XP_004515611.1bHLH family protein
XP_004516755.2bHLH family protein
XP_004517115.1bHLH family protein
XP_012567870.1bHLH family protein
XP_012568171.1bHLH family protein
XP_012568527.1bHLH family protein
XP_012568970.1bHLH family protein
XP_012569388.1bHLH family protein
XP_012569737.1bHLH family protein
XP_012569738.1bHLH family protein
XP_012569753.1bHLH family protein
XP_012569900.1bHLH family protein
XP_012569984.1bHLH family protein
XP_012569985.1bHLH family protein
XP_012569986.1bHLH family protein
XP_012570002.1bHLH family protein
XP_012570134.1bHLH family protein
XP_012570450.1bHLH family protein
XP_012570484.1bHLH family protein
XP_012570505.1bHLH family protein
XP_012570599.1bHLH family protein
XP_012570710.1bHLH family protein
XP_012570795.1bHLH family protein
XP_012571134.1bHLH family protein
XP_012571606.1bHLH family protein
XP_012571906.1bHLH family protein
XP_012572428.1bHLH family protein
XP_012572608.1bHLH family protein
XP_012572662.1bHLH family protein
XP_012572717.1bHLH family protein
XP_012572718.1bHLH family protein
XP_012572839.1bHLH family protein
XP_012573125.1bHLH family protein
XP_012573661.1bHLH family protein
XP_012573662.1bHLH family protein
XP_012573663.1bHLH family protein
XP_012573836.1bHLH family protein
XP_012573945.1bHLH family protein
XP_012573985.1bHLH family protein
XP_012574060.1bHLH family protein
XP_012574061.1bHLH family protein
XP_012574447.1bHLH family protein
XP_012574448.1bHLH family protein
XP_012574618.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250