PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Cicer arietinum
Species TF ID Description
XP_004485623.1MIKC_MADS family protein
XP_004485953.1MIKC_MADS family protein
XP_004485955.1MIKC_MADS family protein
XP_004488426.1MIKC_MADS family protein
XP_004490086.1MIKC_MADS family protein
XP_004490236.1MIKC_MADS family protein
XP_004490237.1MIKC_MADS family protein
XP_004490238.1MIKC_MADS family protein
XP_004490239.1MIKC_MADS family protein
XP_004490359.1MIKC_MADS family protein
XP_004490446.1MIKC_MADS family protein
XP_004490465.1MIKC_MADS family protein
XP_004490466.1MIKC_MADS family protein
XP_004491903.1MIKC_MADS family protein
XP_004491904.1MIKC_MADS family protein
XP_004491906.1MIKC_MADS family protein
XP_004492666.1MIKC_MADS family protein
XP_004492667.1MIKC_MADS family protein
XP_004496628.1MIKC_MADS family protein
XP_004496629.1MIKC_MADS family protein
XP_004498126.1MIKC_MADS family protein
XP_004498359.2MIKC_MADS family protein
XP_004499566.1MIKC_MADS family protein
XP_004499567.1MIKC_MADS family protein
XP_004500961.1MIKC_MADS family protein
XP_004501636.1MIKC_MADS family protein
XP_004501639.1MIKC_MADS family protein
XP_004502274.1MIKC_MADS family protein
XP_004502275.1MIKC_MADS family protein
XP_004502537.1MIKC_MADS family protein
XP_004504256.1MIKC_MADS family protein
XP_004504259.1MIKC_MADS family protein
XP_004504397.1MIKC_MADS family protein
XP_004504398.1MIKC_MADS family protein
XP_004504399.1MIKC_MADS family protein
XP_004504400.1MIKC_MADS family protein
XP_004504870.1MIKC_MADS family protein
XP_004507287.1MIKC_MADS family protein
XP_004507288.1MIKC_MADS family protein
XP_004508656.1MIKC_MADS family protein
XP_004509754.1MIKC_MADS family protein
XP_004510894.1MIKC_MADS family protein
XP_004510895.1MIKC_MADS family protein
XP_004512093.1MIKC_MADS family protein
XP_004512094.1MIKC_MADS family protein
XP_004512095.1MIKC_MADS family protein
XP_004512556.1MIKC_MADS family protein
XP_004513659.1MIKC_MADS family protein
XP_004513661.1MIKC_MADS family protein
XP_004513719.1MIKC_MADS family protein
XP_004513720.1MIKC_MADS family protein
XP_004513721.1MIKC_MADS family protein
XP_004513723.1MIKC_MADS family protein
XP_004513865.1MIKC_MADS family protein
XP_004514527.1MIKC_MADS family protein
XP_004515126.1MIKC_MADS family protein
XP_004515127.1MIKC_MADS family protein
XP_004515128.1MIKC_MADS family protein
XP_004515788.1MIKC_MADS family protein
XP_004515789.1MIKC_MADS family protein
XP_004516227.1MIKC_MADS family protein
XP_012568382.1MIKC_MADS family protein
XP_012568383.1MIKC_MADS family protein
XP_012568384.1MIKC_MADS family protein
XP_012568385.1MIKC_MADS family protein
XP_012568389.1MIKC_MADS family protein
XP_012568390.1MIKC_MADS family protein
XP_012568391.1MIKC_MADS family protein
XP_012568392.1MIKC_MADS family protein
XP_012570954.1MIKC_MADS family protein
XP_012571562.1MIKC_MADS family protein
XP_012571563.1MIKC_MADS family protein
XP_012572287.1MIKC_MADS family protein
XP_012572288.1MIKC_MADS family protein
XP_012572289.1MIKC_MADS family protein
XP_012572503.1MIKC_MADS family protein
XP_012572521.1MIKC_MADS family protein
XP_012572536.1MIKC_MADS family protein
XP_012572595.1MIKC_MADS family protein
XP_012572611.1MIKC_MADS family protein
XP_012573840.1MIKC_MADS family protein
XP_012573841.1MIKC_MADS family protein
XP_012574216.1MIKC_MADS family protein
XP_012574996.1MIKC_MADS family protein
XP_012575382.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513