PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Cicer arietinum
HD-ZIP Family
Species TF ID Description
XP_004489298.1HD-ZIP family protein
XP_012568041.1HD-ZIP family protein
XP_004511225.1HD-ZIP family protein
XP_004489987.1HD-ZIP family protein
XP_004490019.1HD-ZIP family protein
XP_012572245.1HD-ZIP family protein
XP_004504111.1HD-ZIP family protein
XP_004488485.1HD-ZIP family protein
XP_004508941.1HD-ZIP family protein
XP_004489381.1HD-ZIP family protein
XP_004497887.1HD-ZIP family protein
XP_004508776.1HD-ZIP family protein
XP_004493598.1HD-ZIP family protein
XP_004515372.1HD-ZIP family protein
XP_004502402.1HD-ZIP family protein
XP_004511712.1HD-ZIP family protein
XP_004509044.1HD-ZIP family protein
XP_004502034.1HD-ZIP family protein
XP_004502719.1HD-ZIP family protein
XP_004511801.1HD-ZIP family protein
XP_004494126.1HD-ZIP family protein
XP_004501488.1HD-ZIP family protein
XP_004505267.1HD-ZIP family protein
XP_004510630.1HD-ZIP family protein
XP_004497616.1HD-ZIP family protein
XP_004512013.1HD-ZIP family protein
XP_004507924.1HD-ZIP family protein
XP_004488070.2HD-ZIP family protein
XP_004498976.2HD-ZIP family protein
XP_004486751.1HD-ZIP family protein
XP_004515074.1HD-ZIP family protein
XP_004515075.1HD-ZIP family protein
XP_012575640.1HD-ZIP family protein
XP_004487400.1HD-ZIP family protein
XP_004510857.1HD-ZIP family protein
XP_012574211.1HD-ZIP family protein
XP_004492678.1HD-ZIP family protein
XP_004492677.1HD-ZIP family protein
XP_004515249.1HD-ZIP family protein
XP_004515730.1HD-ZIP family protein
XP_004511340.1HD-ZIP family protein
XP_004510296.1HD-ZIP family protein
XP_004510297.1HD-ZIP family protein
XP_004496853.1HD-ZIP family protein
XP_004486776.1HD-ZIP family protein
XP_004486450.1HD-ZIP family protein
XP_012571693.1HD-ZIP family protein
XP_004501146.1HD-ZIP family protein
XP_012571692.1HD-ZIP family protein
XP_012570176.1HD-ZIP family protein
XP_012570177.1HD-ZIP family protein
XP_012570178.1HD-ZIP family protein
XP_012570179.1HD-ZIP family protein
XP_012570175.1HD-ZIP family protein
XP_004496593.1HD-ZIP family protein
XP_004504217.1HD-ZIP family protein
XP_004505999.1HD-ZIP family protein
XP_004487103.1HD-ZIP family protein
XP_004512486.1HD-ZIP family protein
XP_004486568.1HD-ZIP family protein
XP_004486570.1HD-ZIP family protein
XP_004489663.1HD-ZIP family protein
XP_004510020.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401