PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Capsicum annuum
M-type_MADS Family
Species TF ID Description
CA00g00710M-type_MADS family protein
CA00g18810M-type_MADS family protein
CA00g29750M-type_MADS family protein
CA00g29760M-type_MADS family protein
CA00g29780M-type_MADS family protein
CA00g32970M-type_MADS family protein
CA00g41130M-type_MADS family protein
CA00g41340M-type_MADS family protein
CA00g41430M-type_MADS family protein
CA00g44640M-type_MADS family protein
CA00g53740M-type_MADS family protein
CA00g60400M-type_MADS family protein
CA00g60410M-type_MADS family protein
CA00g63480M-type_MADS family protein
CA00g66450M-type_MADS family protein
CA00g67460M-type_MADS family protein
CA00g74560M-type_MADS family protein
CA00g78240M-type_MADS family protein
CA00g87780M-type_MADS family protein
CA00g90400M-type_MADS family protein
CA00g91210M-type_MADS family protein
CA00g91220M-type_MADS family protein
CA00g91670M-type_MADS family protein
CA00g91680M-type_MADS family protein
CA00g92960M-type_MADS family protein
CA00g92970M-type_MADS family protein
CA00g93180M-type_MADS family protein
CA00g93190M-type_MADS family protein
CA00g93670M-type_MADS family protein
CA00g94300M-type_MADS family protein
CA00g95910M-type_MADS family protein
CA00g96350M-type_MADS family protein
CA00g96710M-type_MADS family protein
CA00g97560M-type_MADS family protein
CA01g03610M-type_MADS family protein
CA01g05280M-type_MADS family protein
CA01g05310M-type_MADS family protein
CA01g05320M-type_MADS family protein
CA01g05780M-type_MADS family protein
CA01g10460M-type_MADS family protein
CA01g10480M-type_MADS family protein
CA01g13230M-type_MADS family protein
CA01g27050M-type_MADS family protein
CA01g28790M-type_MADS family protein
CA01g30900M-type_MADS family protein
CA01g30910M-type_MADS family protein
CA01g30930M-type_MADS family protein
CA01g30940M-type_MADS family protein
CA01g30950M-type_MADS family protein
CA01g30970M-type_MADS family protein
CA01g31000M-type_MADS family protein
CA01g31010M-type_MADS family protein
CA01g31020M-type_MADS family protein
CA02g07550M-type_MADS family protein
CA02g19920M-type_MADS family protein
CA02g24310M-type_MADS family protein
CA03g12140M-type_MADS family protein
CA03g13030M-type_MADS family protein
CA03g16030M-type_MADS family protein
CA03g23190M-type_MADS family protein
CA03g24050M-type_MADS family protein
CA03g31360M-type_MADS family protein
CA03g31370M-type_MADS family protein
CA03g31380M-type_MADS family protein
CA03g33840M-type_MADS family protein
CA04g00350M-type_MADS family protein
CA04g00700M-type_MADS family protein
CA04g01240M-type_MADS family protein
CA04g11660M-type_MADS family protein
CA04g13060M-type_MADS family protein
CA04g15180M-type_MADS family protein
CA05g01300M-type_MADS family protein
CA05g16380M-type_MADS family protein
CA05g17430M-type_MADS family protein
CA05g17450M-type_MADS family protein
CA05g17460M-type_MADS family protein
CA06g04230M-type_MADS family protein
CA06g04310M-type_MADS family protein
CA07g12440M-type_MADS family protein
CA07g12450M-type_MADS family protein
CA07g13700M-type_MADS family protein
CA07g18740M-type_MADS family protein
CA07g19290M-type_MADS family protein
CA08g07620M-type_MADS family protein
CA08g11010M-type_MADS family protein
CA08g11020M-type_MADS family protein
CA08g14330M-type_MADS family protein
CA08g15310M-type_MADS family protein
CA08g16320M-type_MADS family protein
CA08g16440M-type_MADS family protein
CA08g17400M-type_MADS family protein
CA09g01730M-type_MADS family protein
CA09g02960M-type_MADS family protein
CA09g02970M-type_MADS family protein
CA09g02990M-type_MADS family protein
CA09g14220M-type_MADS family protein
CA09g14250M-type_MADS family protein
CA09g14270M-type_MADS family protein
CA09g15220M-type_MADS family protein
CA09g15590M-type_MADS family protein
CA10g02830M-type_MADS family protein
CA10g06270M-type_MADS family protein
CA11g03210M-type_MADS family protein
CA11g04720M-type_MADS family protein
CA11g09820M-type_MADS family protein
CA12g03010M-type_MADS family protein
CA12g06290M-type_MADS family protein
CA12g06300M-type_MADS family protein
CA12g06320M-type_MADS family protein
CA12g06340M-type_MADS family protein
CA12g06370M-type_MADS family protein
CA12g13970M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513