PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Capsicum annuum
HD-ZIP Family
Species TF ID Description
CA02g29480HD-ZIP family protein
CA02g28390HD-ZIP family protein
CA11g05100HD-ZIP family protein
CA12g03310HD-ZIP family protein
CA01g05840HD-ZIP family protein
CA02g08550HD-ZIP family protein
CA10g19210HD-ZIP family protein
CA05g13390HD-ZIP family protein
CA01g27890HD-ZIP family protein
CA11g05650HD-ZIP family protein
CA03g28010HD-ZIP family protein
CA04g15670HD-ZIP family protein
CA06g12600HD-ZIP family protein
CA08g08650HD-ZIP family protein
CA02g24650HD-ZIP family protein
CA02g22970HD-ZIP family protein
CA04g16620HD-ZIP family protein
CA02g07270HD-ZIP family protein
CA03g20530HD-ZIP family protein
CA02g05330HD-ZIP family protein
CA07g14020HD-ZIP family protein
CA02g15540HD-ZIP family protein
CA06g08530HD-ZIP family protein
CA04g07110HD-ZIP family protein
CA00g57460HD-ZIP family protein
CA10g01490HD-ZIP family protein
CA01g00300HD-ZIP family protein
CA07g17430HD-ZIP family protein
CA01g17370HD-ZIP family protein
CA10g05400HD-ZIP family protein
CA04g03990HD-ZIP family protein
CA03g34750HD-ZIP family protein
CA01g19070HD-ZIP family protein
CA02g18040HD-ZIP family protein
CA09g07360HD-ZIP family protein
CA03g23110HD-ZIP family protein
CA00g45190HD-ZIP family protein
CA12g13110HD-ZIP family protein
CA03g35060HD-ZIP family protein
CA02g10530HD-ZIP family protein
CA03g16380HD-ZIP family protein
CA06g20810HD-ZIP family protein
CA11g18960HD-ZIP family protein
CA01g07870HD-ZIP family protein
CA12g00830HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401