PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Beta vulgaris
HD-ZIP Family
Species TF ID Description
Bv6_144930_oqgf.t1HD-ZIP family protein
Bv6_154310_ccop.t1HD-ZIP family protein
Bv6_138670_qaws.t1HD-ZIP family protein
Bv_009450_upnr.t1HD-ZIP family protein
Bv5_104730_xsdz.t1HD-ZIP family protein
Bv5_115220_ueci.t1HD-ZIP family protein
Bv3_060000_xtmt.t1HD-ZIP family protein
Bv6_154690_swdf.t1HD-ZIP family protein
Bv6_137340_fcae.t1HD-ZIP family protein
Bv6_139660_wjii.t1HD-ZIP family protein
Bv_000370_cufa.t1HD-ZIP family protein
Bv1_018000_grua.t1HD-ZIP family protein
Bv1_002480_nawq.t1HD-ZIP family protein
Bv7_160720_jzkt.t2HD-ZIP family protein
Bv7_160720_jzkt.t1HD-ZIP family protein
Bv4_083830_qnrf.t1HD-ZIP family protein
Bv8_182430_wwwi.t1HD-ZIP family protein
Bv5_104030_mied.t1HD-ZIP family protein
Bv9_221020_azmu.t1HD-ZIP family protein
Bv8_200210_uzdz.t1HD-ZIP family protein
Bv1_005690_hemo.t1HD-ZIP family protein
Bv9_221790_dgis.t1HD-ZIP family protein
Bv2_032530_xysi.t1HD-ZIP family protein
Bv3_066300_hpks.t2HD-ZIP family protein
Bv3_066300_hpks.t1HD-ZIP family protein
Bv9_207830_hxcw.t1HD-ZIP family protein
Bv5_106950_iwui.t1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401