PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Brachypodium stacei
bHLH Family
Species TF ID Description
Brast01G018700.1.pbHLH family protein
Brast01G019500.1.pbHLH family protein
Brast01G036600.1.pbHLH family protein
Brast01G047000.1.pbHLH family protein
Brast01G056400.1.pbHLH family protein
Brast01G099600.1.pbHLH family protein
Brast01G122500.1.pbHLH family protein
Brast01G169200.1.pbHLH family protein
Brast01G170100.1.pbHLH family protein
Brast01G237800.1.pbHLH family protein
Brast01G241100.1.pbHLH family protein
Brast01G272500.1.pbHLH family protein
Brast01G287300.1.pbHLH family protein
Brast01G289500.1.pbHLH family protein
Brast01G326200.1.pbHLH family protein
Brast01G338300.1.pbHLH family protein
Brast01G352200.1.pbHLH family protein
Brast01G375800.1.pbHLH family protein
Brast01G380300.1.pbHLH family protein
Brast01G407100.1.pbHLH family protein
Brast01G409600.1.pbHLH family protein
Brast01G409700.1.pbHLH family protein
Brast01G409800.1.pbHLH family protein
Brast02G020500.1.pbHLH family protein
Brast02G027200.1.pbHLH family protein
Brast02G032500.1.pbHLH family protein
Brast02G032500.2.pbHLH family protein
Brast02G032500.3.pbHLH family protein
Brast02G058200.1.pbHLH family protein
Brast02G058400.1.pbHLH family protein
Brast02G072700.1.pbHLH family protein
Brast02G084900.1.pbHLH family protein
Brast02G103100.1.pbHLH family protein
Brast02G103100.2.pbHLH family protein
Brast02G104400.1.pbHLH family protein
Brast02G104400.2.pbHLH family protein
Brast02G122500.1.pbHLH family protein
Brast02G135000.1.pbHLH family protein
Brast02G197500.1.pbHLH family protein
Brast02G233800.1.pbHLH family protein
Brast02G242100.1.pbHLH family protein
Brast02G242100.2.pbHLH family protein
Brast02G242100.3.pbHLH family protein
Brast02G258700.1.pbHLH family protein
Brast02G259000.1.pbHLH family protein
Brast02G289700.1.pbHLH family protein
Brast02G292100.1.pbHLH family protein
Brast02G292100.2.pbHLH family protein
Brast02G292100.3.pbHLH family protein
Brast02G292100.4.pbHLH family protein
Brast02G292100.5.pbHLH family protein
Brast02G292100.6.pbHLH family protein
Brast02G292100.7.pbHLH family protein
Brast02G292100.8.pbHLH family protein
Brast02G301200.1.pbHLH family protein
Brast02G315300.1.pbHLH family protein
Brast02G328800.1.pbHLH family protein
Brast02G341400.1.pbHLH family protein
Brast02G345200.1.pbHLH family protein
Brast02G354300.1.pbHLH family protein
Brast02G354300.2.pbHLH family protein
Brast03G030600.1.pbHLH family protein
Brast03G038800.1.pbHLH family protein
Brast03G053300.1.pbHLH family protein
Brast03G093900.1.pbHLH family protein
Brast03G093900.2.pbHLH family protein
Brast03G195900.1.pbHLH family protein
Brast03G208300.1.pbHLH family protein
Brast03G236600.1.pbHLH family protein
Brast03G254700.1.pbHLH family protein
Brast03G256100.1.pbHLH family protein
Brast03G257700.1.pbHLH family protein
Brast03G262200.1.pbHLH family protein
Brast03G263100.1.pbHLH family protein
Brast03G263100.2.pbHLH family protein
Brast03G273700.1.pbHLH family protein
Brast03G284900.1.pbHLH family protein
Brast03G292200.1.pbHLH family protein
Brast03G297000.1.pbHLH family protein
Brast04G017700.1.pbHLH family protein
Brast04G025900.1.pbHLH family protein
Brast04G048900.1.pbHLH family protein
Brast04G048900.2.pbHLH family protein
Brast04G069100.1.pbHLH family protein
Brast04G069100.2.pbHLH family protein
Brast04G076400.1.pbHLH family protein
Brast04G087900.1.pbHLH family protein
Brast04G091000.1.pbHLH family protein
Brast04G098700.1.pbHLH family protein
Brast04G145900.1.pbHLH family protein
Brast04G145900.2.pbHLH family protein
Brast04G166600.1.pbHLH family protein
Brast04G166600.2.pbHLH family protein
Brast04G176600.1.pbHLH family protein
Brast04G176700.1.pbHLH family protein
Brast04G203300.1.pbHLH family protein
Brast04G205100.1.pbHLH family protein
Brast04G231300.1.pbHLH family protein
Brast04G243600.1.pbHLH family protein
Brast04G249800.1.pbHLH family protein
Brast04G249800.2.pbHLH family protein
Brast04G326000.1.pbHLH family protein
Brast04G326100.1.pbHLH family protein
Brast04G326100.2.pbHLH family protein
Brast04G329700.1.pbHLH family protein
Brast05G074700.1.pbHLH family protein
Brast05G107300.1.pbHLH family protein
Brast05G114700.1.pbHLH family protein
Brast05G121900.1.pbHLH family protein
Brast05G126200.1.pbHLH family protein
Brast05G126200.2.pbHLH family protein
Brast05G145900.1.pbHLH family protein
Brast05G150900.1.pbHLH family protein
Brast05G152900.1.pbHLH family protein
Brast05G155500.1.pbHLH family protein
Brast05G155500.2.pbHLH family protein
Brast05G164600.1.pbHLH family protein
Brast05G164600.2.pbHLH family protein
Brast05G172000.1.pbHLH family protein
Brast05G172000.2.pbHLH family protein
Brast05G177900.1.pbHLH family protein
Brast05G177900.2.pbHLH family protein
Brast05G177900.3.pbHLH family protein
Brast05G177900.4.pbHLH family protein
Brast05G184100.1.pbHLH family protein
Brast06G019300.1.pbHLH family protein
Brast06G070800.1.pbHLH family protein
Brast06G099300.1.pbHLH family protein
Brast06G102600.1.pbHLH family protein
Brast06G178200.1.pbHLH family protein
Brast06G178200.2.pbHLH family protein
Brast06G183200.1.pbHLH family protein
Brast06G187200.1.pbHLH family protein
Brast06G226700.1.pbHLH family protein
Brast07G045300.1.pbHLH family protein
Brast07G056600.1.pbHLH family protein
Brast07G063600.1.pbHLH family protein
Brast07G063600.2.pbHLH family protein
Brast07G063600.3.pbHLH family protein
Brast07G063600.4.pbHLH family protein
Brast07G071400.1.pbHLH family protein
Brast07G081600.1.pbHLH family protein
Brast07G101100.1.pbHLH family protein
Brast07G114700.1.pbHLH family protein
Brast07G136300.1.pbHLH family protein
Brast07G150800.1.pbHLH family protein
Brast07G168900.1.pbHLH family protein
Brast07G168900.2.pbHLH family protein
Brast07G191400.1.pbHLH family protein
Brast07G237400.1.pbHLH family protein
Brast08G041700.1.pbHLH family protein
Brast08G070700.1.pbHLH family protein
Brast08G070700.2.pbHLH family protein
Brast08G091300.1.pbHLH family protein
Brast08G099100.1.pbHLH family protein
Brast08G193000.1.pbHLH family protein
Brast08G196400.1.pbHLH family protein
Brast08G214800.1.pbHLH family protein
Brast08G248600.1.pbHLH family protein
Brast09G016600.1.pbHLH family protein
Brast09G043400.1.pbHLH family protein
Brast09G056000.1.pbHLH family protein
Brast09G188800.1.pbHLH family protein
Brast09G193000.1.pbHLH family protein
Brast09G210500.1.pbHLH family protein
Brast09G221600.1.pbHLH family protein
Brast09G229700.1.pbHLH family protein
Brast10G007900.1.pbHLH family protein
Brast10G025900.1.pbHLH family protein
Brast10G026000.1.pbHLH family protein
Brast10G026300.1.pbHLH family protein
Brast10G030800.1.pbHLH family protein
Brast10G073000.1.pbHLH family protein
Brast10G110600.1.pbHLH family protein
Brast10G110600.2.pbHLH family protein
Brast10G148100.1.pbHLH family protein
Brast10G162400.1.pbHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250