PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Brachypodium stacei
HD-ZIP Family
Species TF ID Description
Brast05G153800.1.pHD-ZIP family protein
Brast04G050700.1.pHD-ZIP family protein
Brast03G227900.1.pHD-ZIP family protein
Brast03G258700.1.pHD-ZIP family protein
Brast02G057700.1.pHD-ZIP family protein
Brast03G250100.1.pHD-ZIP family protein
Brast02G073200.1.pHD-ZIP family protein
Brast05G142000.1.pHD-ZIP family protein
Brast03G198700.1.pHD-ZIP family protein
Brast09G163400.1.pHD-ZIP family protein
Brast03G094900.1.pHD-ZIP family protein
Brast03G094900.2.pHD-ZIP family protein
Brast02G103800.1.pHD-ZIP family protein
Brast09G158900.1.pHD-ZIP family protein
Brast05G114800.1.pHD-ZIP family protein
Brast05G190200.1.pHD-ZIP family protein
Brast04G121000.1.pHD-ZIP family protein
Brast04G165400.1.pHD-ZIP family protein
Brast07G012900.1.pHD-ZIP family protein
Brast01G202300.1.pHD-ZIP family protein
Brast07G012800.1.pHD-ZIP family protein
Brast06G076900.1.pHD-ZIP family protein
Brast07G194700.1.pHD-ZIP family protein
Brast02G080500.1.pHD-ZIP family protein
Brast04G301100.1.pHD-ZIP family protein
Brast03G121500.1.pHD-ZIP family protein
Brast03G031800.1.pHD-ZIP family protein
Brast09G218300.1.pHD-ZIP family protein
Brast09G218300.2.pHD-ZIP family protein
Brast04G106600.1.pHD-ZIP family protein
Brast01G139000.1.pHD-ZIP family protein
Brast10G017900.1.pHD-ZIP family protein
Brast02G242900.1.pHD-ZIP family protein
Brast01G349400.2.pHD-ZIP family protein
Brast01G349400.1.pHD-ZIP family protein
Brast05G188400.2.pHD-ZIP family protein
Brast05G188400.1.pHD-ZIP family protein
Brast03G039800.1.pHD-ZIP family protein
Brast03G152300.1.pHD-ZIP family protein
Brast03G152300.2.pHD-ZIP family protein
Brast04G034900.1.pHD-ZIP family protein
Brast09G175500.1.pHD-ZIP family protein
Brast07G069700.1.pHD-ZIP family protein
Brast03G210700.1.pHD-ZIP family protein
Brast08G166200.1.pHD-ZIP family protein
Brast01G120700.1.pHD-ZIP family protein
Brast06G214300.1.pHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401