PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Brassica oleracea
HD-ZIP Family
Species TF ID Description
XP_013618241.1HD-ZIP family protein
XP_013590056.1HD-ZIP family protein
XP_013589953.1HD-ZIP family protein
XP_013622099.1HD-ZIP family protein
XP_013606550.1HD-ZIP family protein
XP_013609294.1HD-ZIP family protein
XP_013639193.1HD-ZIP family protein
XP_013618604.1HD-ZIP family protein
XP_013585413.1HD-ZIP family protein
XP_013609167.1HD-ZIP family protein
XP_013605522.1HD-ZIP family protein
XP_013609158.1HD-ZIP family protein
XP_013609150.1HD-ZIP family protein
XP_013613639.1HD-ZIP family protein
XP_013623152.1HD-ZIP family protein
XP_013631195.1HD-ZIP family protein
XP_013626571.1HD-ZIP family protein
XP_013584528.1HD-ZIP family protein
XP_013633686.1HD-ZIP family protein
XP_013610091.1HD-ZIP family protein
XP_013583998.1HD-ZIP family protein
XP_013596506.1HD-ZIP family protein
XP_013596505.1HD-ZIP family protein
XP_013593591.1HD-ZIP family protein
XP_013609720.1HD-ZIP family protein
XP_013609718.1HD-ZIP family protein
XP_013637658.1HD-ZIP family protein
XP_013600065.1HD-ZIP family protein
XP_013631726.1HD-ZIP family protein
XP_013621022.1HD-ZIP family protein
XP_013627348.1HD-ZIP family protein
XP_013595686.1HD-ZIP family protein
XP_013636576.1HD-ZIP family protein
XP_013595897.1HD-ZIP family protein
XP_013595896.1HD-ZIP family protein
XP_013635747.1HD-ZIP family protein
XP_013600291.1HD-ZIP family protein
XP_013596522.1HD-ZIP family protein
XP_013593815.1HD-ZIP family protein
XP_013631796.1HD-ZIP family protein
XP_013610076.1HD-ZIP family protein
XP_013636619.1HD-ZIP family protein
XP_013602049.1HD-ZIP family protein
XP_013590148.1HD-ZIP family protein
XP_013619404.1HD-ZIP family protein
XP_013619403.1HD-ZIP family protein
XP_013609037.1HD-ZIP family protein
XP_013596523.1HD-ZIP family protein
XP_013627901.1HD-ZIP family protein
XP_013633906.1HD-ZIP family protein
XP_013610664.1HD-ZIP family protein
XP_013610665.1HD-ZIP family protein
XP_013619786.1HD-ZIP family protein
XP_013584390.1HD-ZIP family protein
XP_013608549.1HD-ZIP family protein
XP_013635693.1HD-ZIP family protein
XP_013635691.1HD-ZIP family protein
XP_013594714.1HD-ZIP family protein
XP_013618746.1HD-ZIP family protein
XP_013590457.1HD-ZIP family protein
XP_013590514.1HD-ZIP family protein
XP_013619929.1HD-ZIP family protein
XP_013590784.1HD-ZIP family protein
XP_013605632.1HD-ZIP family protein
XP_013605633.1HD-ZIP family protein
XP_013605634.1HD-ZIP family protein
XP_013605635.1HD-ZIP family protein
XP_013605636.1HD-ZIP family protein
XP_013605637.1HD-ZIP family protein
XP_013605638.1HD-ZIP family protein
XP_013629800.1HD-ZIP family protein
XP_013629801.1HD-ZIP family protein
XP_013598423.1HD-ZIP family protein
XP_013598424.1HD-ZIP family protein
XP_013598425.1HD-ZIP family protein
XP_013586642.1HD-ZIP family protein
XP_013586641.1HD-ZIP family protein
XP_013629750.1HD-ZIP family protein
XP_013630219.1HD-ZIP family protein
XP_013611160.1HD-ZIP family protein
XP_013611161.1HD-ZIP family protein
XP_013611162.1HD-ZIP family protein
XP_013611163.1HD-ZIP family protein
XP_013612299.1HD-ZIP family protein
XP_013623995.1HD-ZIP family protein
XP_013623820.1HD-ZIP family protein
XP_013623905.1HD-ZIP family protein
XP_013623953.1HD-ZIP family protein
XP_013623587.1HD-ZIP family protein
XP_013623666.1HD-ZIP family protein
XP_013623723.1HD-ZIP family protein
XP_013623776.1HD-ZIP family protein
XP_013623861.1HD-ZIP family protein
XP_013622315.1HD-ZIP family protein
XP_013637594.1HD-ZIP family protein
XP_013592301.1HD-ZIP family protein
XP_013637558.1HD-ZIP family protein
XP_013637263.1HD-ZIP family protein
XP_013637556.1HD-ZIP family protein
XP_013637557.1HD-ZIP family protein
XP_013637264.1HD-ZIP family protein
XP_013613235.1HD-ZIP family protein
XP_013587486.1HD-ZIP family protein
XP_013587487.1HD-ZIP family protein
XP_013592012.1HD-ZIP family protein
XP_013621760.1HD-ZIP family protein
XP_013634261.1HD-ZIP family protein
XP_013634882.1HD-ZIP family protein
XP_013588523.1HD-ZIP family protein
XP_013623090.1HD-ZIP family protein
XP_013623089.1HD-ZIP family protein
XP_013611543.1HD-ZIP family protein
XP_013612427.1HD-ZIP family protein
XP_013613976.1HD-ZIP family protein
XP_013613977.1HD-ZIP family protein
XP_013602839.1HD-ZIP family protein
XP_013592873.1HD-ZIP family protein
XP_013607209.1HD-ZIP family protein
XP_013607210.1HD-ZIP family protein
XP_013607211.1HD-ZIP family protein
XP_013601964.1HD-ZIP family protein
XP_013615089.1HD-ZIP family protein
XP_013610327.1HD-ZIP family protein
XP_013619236.1HD-ZIP family protein
XP_013590801.1HD-ZIP family protein
XP_013584487.1HD-ZIP family protein
XP_013591191.1HD-ZIP family protein
XP_013619678.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401