PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Brassica napus
MIKC_MADS Family
Species TF ID Description
GSBRNA2T00000786001MIKC_MADS family protein
GSBRNA2T00000787001MIKC_MADS family protein
GSBRNA2T00001530001MIKC_MADS family protein
GSBRNA2T00002955001MIKC_MADS family protein
GSBRNA2T00006113001MIKC_MADS family protein
GSBRNA2T00006114001MIKC_MADS family protein
GSBRNA2T00006788001MIKC_MADS family protein
GSBRNA2T00011645001MIKC_MADS family protein
GSBRNA2T00011646001MIKC_MADS family protein
GSBRNA2T00016119001MIKC_MADS family protein
GSBRNA2T00016124001MIKC_MADS family protein
GSBRNA2T00017223001MIKC_MADS family protein
GSBRNA2T00017372001MIKC_MADS family protein
GSBRNA2T00020288001MIKC_MADS family protein
GSBRNA2T00022303001MIKC_MADS family protein
GSBRNA2T00024568001MIKC_MADS family protein
GSBRNA2T00024665001MIKC_MADS family protein
GSBRNA2T00025013001MIKC_MADS family protein
GSBRNA2T00028475001MIKC_MADS family protein
GSBRNA2T00028543001MIKC_MADS family protein
GSBRNA2T00029970001MIKC_MADS family protein
GSBRNA2T00032893001MIKC_MADS family protein
GSBRNA2T00035264001MIKC_MADS family protein
GSBRNA2T00037309001MIKC_MADS family protein
GSBRNA2T00038348001MIKC_MADS family protein
GSBRNA2T00046036001MIKC_MADS family protein
GSBRNA2T00047035001MIKC_MADS family protein
GSBRNA2T00047451001MIKC_MADS family protein
GSBRNA2T00047454001MIKC_MADS family protein
GSBRNA2T00047455001MIKC_MADS family protein
GSBRNA2T00048277001MIKC_MADS family protein
GSBRNA2T00048970001MIKC_MADS family protein
GSBRNA2T00050088001MIKC_MADS family protein
GSBRNA2T00051079001MIKC_MADS family protein
GSBRNA2T00051175001MIKC_MADS family protein
GSBRNA2T00052175001MIKC_MADS family protein
GSBRNA2T00052638001MIKC_MADS family protein
GSBRNA2T00053782001MIKC_MADS family protein
GSBRNA2T00054833001MIKC_MADS family protein
GSBRNA2T00055278001MIKC_MADS family protein
GSBRNA2T00055843001MIKC_MADS family protein
GSBRNA2T00055849001MIKC_MADS family protein
GSBRNA2T00056321001MIKC_MADS family protein
GSBRNA2T00056989001MIKC_MADS family protein
GSBRNA2T00057239001MIKC_MADS family protein
GSBRNA2T00059332001MIKC_MADS family protein
GSBRNA2T00059911001MIKC_MADS family protein
GSBRNA2T00062460001MIKC_MADS family protein
GSBRNA2T00063263001MIKC_MADS family protein
GSBRNA2T00064974001MIKC_MADS family protein
GSBRNA2T00066097001MIKC_MADS family protein
GSBRNA2T00066725001MIKC_MADS family protein
GSBRNA2T00066728001MIKC_MADS family protein
GSBRNA2T00068419001MIKC_MADS family protein
GSBRNA2T00068991001MIKC_MADS family protein
GSBRNA2T00071086001MIKC_MADS family protein
GSBRNA2T00071267001MIKC_MADS family protein
GSBRNA2T00071718001MIKC_MADS family protein
GSBRNA2T00071997001MIKC_MADS family protein
GSBRNA2T00073102001MIKC_MADS family protein
GSBRNA2T00074919001MIKC_MADS family protein
GSBRNA2T00075532001MIKC_MADS family protein
GSBRNA2T00075572001MIKC_MADS family protein
GSBRNA2T00076141001MIKC_MADS family protein
GSBRNA2T00076267001MIKC_MADS family protein
GSBRNA2T00077589001MIKC_MADS family protein
GSBRNA2T00078179001MIKC_MADS family protein
GSBRNA2T00081381001MIKC_MADS family protein
GSBRNA2T00082681001MIKC_MADS family protein
GSBRNA2T00082884001MIKC_MADS family protein
GSBRNA2T00083011001MIKC_MADS family protein
GSBRNA2T00086507001MIKC_MADS family protein
GSBRNA2T00087024001MIKC_MADS family protein
GSBRNA2T00089502001MIKC_MADS family protein
GSBRNA2T00089950001MIKC_MADS family protein
GSBRNA2T00092647001MIKC_MADS family protein
GSBRNA2T00092702001MIKC_MADS family protein
GSBRNA2T00092816001MIKC_MADS family protein
GSBRNA2T00094672001MIKC_MADS family protein
GSBRNA2T00094717001MIKC_MADS family protein
GSBRNA2T00094727001MIKC_MADS family protein
GSBRNA2T00095550001MIKC_MADS family protein
GSBRNA2T00098053001MIKC_MADS family protein
GSBRNA2T00098861001MIKC_MADS family protein
GSBRNA2T00098954001MIKC_MADS family protein
GSBRNA2T00099980001MIKC_MADS family protein
GSBRNA2T00101933001MIKC_MADS family protein
GSBRNA2T00101980001MIKC_MADS family protein
GSBRNA2T00102484001MIKC_MADS family protein
GSBRNA2T00103205001MIKC_MADS family protein
GSBRNA2T00105875001MIKC_MADS family protein
GSBRNA2T00106627001MIKC_MADS family protein
GSBRNA2T00106863001MIKC_MADS family protein
GSBRNA2T00107731001MIKC_MADS family protein
GSBRNA2T00109002001MIKC_MADS family protein
GSBRNA2T00109576001MIKC_MADS family protein
GSBRNA2T00110066001MIKC_MADS family protein
GSBRNA2T00110227001MIKC_MADS family protein
GSBRNA2T00110351001MIKC_MADS family protein
GSBRNA2T00112231001MIKC_MADS family protein
GSBRNA2T00113543001MIKC_MADS family protein
GSBRNA2T00113594001MIKC_MADS family protein
GSBRNA2T00113632001MIKC_MADS family protein
GSBRNA2T00113855001MIKC_MADS family protein
GSBRNA2T00115275001MIKC_MADS family protein
GSBRNA2T00116099001MIKC_MADS family protein
GSBRNA2T00116497001MIKC_MADS family protein
GSBRNA2T00116722001MIKC_MADS family protein
GSBRNA2T00116723001MIKC_MADS family protein
GSBRNA2T00117397001MIKC_MADS family protein
GSBRNA2T00117846001MIKC_MADS family protein
GSBRNA2T00118005001MIKC_MADS family protein
GSBRNA2T00121299001MIKC_MADS family protein
GSBRNA2T00121622001MIKC_MADS family protein
GSBRNA2T00121984001MIKC_MADS family protein
GSBRNA2T00124318001MIKC_MADS family protein
GSBRNA2T00126445001MIKC_MADS family protein
GSBRNA2T00126728001MIKC_MADS family protein
GSBRNA2T00127429001MIKC_MADS family protein
GSBRNA2T00129741001MIKC_MADS family protein
GSBRNA2T00129941001MIKC_MADS family protein
GSBRNA2T00130071001MIKC_MADS family protein
GSBRNA2T00130794001MIKC_MADS family protein
GSBRNA2T00131190001MIKC_MADS family protein
GSBRNA2T00131396001MIKC_MADS family protein
GSBRNA2T00132708001MIKC_MADS family protein
GSBRNA2T00134620001MIKC_MADS family protein
GSBRNA2T00135493001MIKC_MADS family protein
GSBRNA2T00135921001MIKC_MADS family protein
GSBRNA2T00140350001MIKC_MADS family protein
GSBRNA2T00140505001MIKC_MADS family protein
GSBRNA2T00142187001MIKC_MADS family protein
GSBRNA2T00142288001MIKC_MADS family protein
GSBRNA2T00143535001MIKC_MADS family protein
GSBRNA2T00144478001MIKC_MADS family protein
GSBRNA2T00144676001MIKC_MADS family protein
GSBRNA2T00145444001MIKC_MADS family protein
GSBRNA2T00146106001MIKC_MADS family protein
GSBRNA2T00146477001MIKC_MADS family protein
GSBRNA2T00146480001MIKC_MADS family protein
GSBRNA2T00147935001MIKC_MADS family protein
GSBRNA2T00148924001MIKC_MADS family protein
GSBRNA2T00149041001MIKC_MADS family protein
GSBRNA2T00149118001MIKC_MADS family protein
GSBRNA2T00149230001MIKC_MADS family protein
GSBRNA2T00149752001MIKC_MADS family protein
GSBRNA2T00149769001MIKC_MADS family protein
GSBRNA2T00150996001MIKC_MADS family protein
GSBRNA2T00151432001MIKC_MADS family protein
GSBRNA2T00153123001MIKC_MADS family protein
GSBRNA2T00154251001MIKC_MADS family protein
GSBRNA2T00154448001MIKC_MADS family protein
GSBRNA2T00155673001MIKC_MADS family protein
GSBRNA2T00155831001MIKC_MADS family protein
GSBRNA2T00157596001MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513